Databases and in silico tools for vaccine design.
Databases and in silico tools for vaccine design.
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DOI：
10.1007/978-1-62703-342-8_8
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发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Xiang, Zuoshuang
中科院分区：
文献类型：
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作者：
He, Yongqun;Xiang, Zuoshuang
在疫苗设计中，数据库和计算机工具发挥着不同但互补的作用。数据库收集经过实验验证的疫苗和疫苗成分，计算机工具提供了预测和设计新疫苗和疫苗成分的计算方法。与疫苗有关的数据库包括疫苗和疫苗成分数据库。在美国，食品和药物管理局（FDA）有一个已获许可的人用疫苗数据库，美国农业部有一个已获许可的动物用疫苗数据库。还存在疫苗临床试验和研究中的疫苗数据库。重要的疫苗成分包括疫苗抗原、疫苗佐剂、疫苗载体和非疫苗防腐剂。疫苗抗原可以是完整的蛋白质或免疫表位。各种硅疫苗设计工具也可用。疫苗调查与在线信息网（小提琴；http://www.violinet.org）是一个综合性的疫苗数据库和分析系统。小提琴数据库包括各种类型的疫苗和疫苗成分。小提琴还包括Vaxign，一个基于网络的基于反向疫苗学策略的硅疫苗设计程序。疫苗信息和资源可以集成到疫苗本体（Vaccine Ontology， VO）中。本章介绍了促进疫苗设计的数据库和计算机工具，特别是小提琴系统中的工具。
In vaccine design, databases and in silico tools play different but complementary roles. Databases collect experimentally verified vaccines and vaccine components, and in silico tools provide computational methods to predict and design new vaccines and vaccine components. Vaccine-related databases include databases of vaccines and vaccine components. In the USA, the Food and Drug Administration (FDA) maintains a database of licensed human vaccines, and the US Department of Agriculture keeps a database of licensed animal vaccines. Databases of vaccine clinical trials and vaccines in research also exist. The important vaccine components include vaccine antigens, vaccine adjuvants, vaccine vectors, and -vaccine preservatives. The vaccine antigens can be whole proteins or immune epitopes. Various in silico vaccine design tools are also available. The Vaccine Investigation and Online Information Network (VIOLIN; http://www.violinet.org ) is a comprehensive vaccine database and analysis system. The VIOLIN database includes various types of vaccines and vaccine components. VIOLIN also includes Vaxign, a Web-based in silico vaccine design program based on the reverse vaccinology strategy. Vaccine information and resources can be integrated with Vaccine Ontology (VO). This chapter introduces databases and in silico tools that facilitate vaccine design, especially those in the VIOLIN system.