A New Sonographic Weight Estimation Formula for Fetuses with Congenital Diaphragmatic Hernia
A New Sonographic Weight Estimation Formula for Fetuses with Congenital Diaphragmatic Hernia
复制标题
先天性膈疝胎儿超声体重估算新公式
DOI：
10.1055/s-0034-1366517
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发表时间：
2014
影响因子：
3.4
通讯作者：
M. Schmid
中科院分区：
文献类型：
--
作者：
F. Faschingbauer;Andreas Mayr;A. Geipel;Ulrich Gembruch;Ulf Dammer;E. Raabe;M. Beckmann;S. Kehl;R. Schild;J. Siemer;M. Schmid
摘要目的：先天性膈疝（CDH）胎儿超声体重估计（WE）的准确性明显低于无畸形胎儿。本研究的目的是开发和评估第一个特定的超声体重公式胎儿CDH。材料和方法：在一项回顾性、多中心、队列研究中，一种被称为“多变量分数多项式回归”的统计估计技术应用于146例CDH胎儿。每个胎儿在分娩后7天内进行超声检查，并提供完整的生物特征参数。利用得到的数据推导出一个新的公式，并与其他常用方程进行了比较。使用有符号百分比误差均值（SPE）、绝对百分比误差中位数（MAPE）和预估误差范围内的分数来比较不同公式的准确性。结果：新的推导公式为：EFW = 10^(4.6729 107 371 + 0.2365 011 768 * HC + 0.2228 897 682 * FL^2 - 0.0129 895 773 * FL^3 - 1.0470 039 072 * (FL * HC)^0.5 + 0.0004 314 661 * (AC * HC) -[肝疝时]0.0062 112 122)，其中EFW为胎儿估计体重，HC为头围，AC为腹围，FL为股骨长。结果表明，新公式具有最低的中位数绝对百分比误差（MAE: 6.97）和平均有符号百分比误差（SPE: 0.40），并且绝对百分比误差在预定误差范围内的最佳分布。结论：新配方可显著改善CDH胎儿的体重估计。
Abstract Purpose: The accuracy of the sonographic weight estimation (WE) of fetuses with congenital diaphragmatic hernia (CDH) is significantly lower than that of fetuses without any malformations. The objective of this study was to develop and evaluate the first specific sonographic weight formula for fetuses with CDH. Materials and Methods: In a retrospective, multicenter, cohort study, a statistical estimation technique known as “multivariable fractional polynomial regression” was applied to a group of 146 fetuses with CDH. Each fetus underwent an ultrasound examination with complete biometric parameters within 7 days of delivery. A new formula was derived using the obtained data and was then compared with other commonly used equations. The accuracy of the different formulas was compared using means of signed percentage errors (SPE), medians of absolute percentage errors (MAPE), and fractions of estimates within prespecified error bounds. Results: The new derived formula is: EFW = 10^(4.6729 107 371 + 0.2365 011 768 * HC + 0.2228 897 682 * FL^2 – 0.0129 895 773 * FL^3 – 1.0470 039 072 * (FL * HC)^0.5 + 0.0004 314 661 * (AC * HC) – [in case of liver herniation] 0.0062 112 122), where EFW is the estimated fetal weight, HC is the head circumference, AC is the abdominal circumference, and FL is the femur length. The new formula proved to be superior to other established equations, showing both the lowest median absolute percentage error (MAE: 6.97) and mean signed percentage error (SPE: 0.40), and the best distribution of absolute percentage errors within prespecified error bounds. Conclusion: This new formula significantly improves weight estimation in fetuses with CDH.