Singlet Molecular Oxygen: from COIL Lasers to Photodynamic Cancer Therapy.
Singlet Molecular Oxygen: from COIL Lasers to Photodynamic Cancer Therapy.
复制标题
单线态分子氧：从线圈激光器到光动力癌症治疗。
DOI：
10.1021/acs.jpcb.2c07330
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Pogue,BW
中科院分区：
文献类型：
--
作者：
Davis,SJ;Zhao,Y;Yu,TC;Maytin,EV;Anand,S;Hasan,T;Pogue,BW
将实验技术从一个学科转换到另一个学科通常是困难的，但也是有益的。从新领域获得的知识可以导致长期持久和富有成效的合作，伴随着新思想和研究的发展。在这篇评论文章中，我们描述了化学泵原子碘激光器（COIL）的早期工作如何导致开发出一种有前途的癌症治疗（称为光动力疗法（PDT））的关键诊断方法。分子氧的高度亚稳态激发态a1Δg，也称为单线态氧，是这些不同场之间的联系。它为COIL激光器提供动力，是PDT过程中杀死癌细胞的活性物质。我们描述了COIL和PDT的基本原理，并追踪了单态氧超灵敏剂量计的发展路径。从COIL激光器到癌症研究的道路相对较长，需要来自众多合作的医学和工程专业知识。正如我们下面所示，在COIL研究中获得的知识，加上这些广泛的合作，使我们能够显示癌细胞死亡与小鼠PDT治疗期间测量的单线态氧之间的强相关性。这一进展是最终开发单线态氧剂量计的关键一步，该剂量计可用于指导PDT治疗并改善结果。
Translation of experimental techniques from one scientific discipline to another is often difficult but rewarding. Knowledge gained from the new area can lead to long lasting and fruitful collaborations with concomitant development of new ideas and studies. In this Review Article, we describe how early work on the chemically pumped atomic iodine laser (COIL) led to the development of a key diagnostic for a promising cancer treatment known as photodynamic therapy (PDT). The highly metastable excited state of molecular oxygen, a1Δg, also known as singlet oxygen, is the link between these disparate fields. It powers the COIL laser and is the active species that kills cancer cells during PDT. We describe the fundamentals of both COIL and PDT and trace the development path of an ultrasensitive dosimeter for singlet oxygen. The path from COIL lasers to cancer research was relatively long and required medical and engineering expertise from numerous collaborations. As we show below, the knowledge gained in the COIL research, combined with these extensive collaborations, has resulted in our being able to show a strong correlation between cancer cell death and the singlet oxygen measured during PDT treatments of mice. This progress is a key step in the eventual development of a singlet oxygen dosimeter that could be used to guide PDT treatments and improve outcomes.