Advances in interpenetrating polymer network hydrogels and their applications
Advances in interpenetrating polymer network hydrogels and their applications
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DOI：
10.1515/pac-2014-0713
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发表时间：
2014-11-01
影响因子：
1.8
通讯作者：
Dragan, Ecaterina Stela
中科院分区：
文献类型：
--
作者：
Dragan, Ecaterina Stela
互穿聚合物网络（IPN）水凝胶与单网络水凝胶相比带来了明显的益处，如更广泛的可控物理性质，以及（通常）更有效的药物装载/释放。然而，IPN策略不足以设计具有再生医学所需的增强机械性能的水凝胶，如天然软骨或人工角膜的替代。本文综述了近十年来为制备满足这些要求的互穿网络水凝胶而提出的一些新技术。其中，“双网络”策略在开发各种水凝胶方面做出了巨大贡献，这些水凝胶在含水量高达90%时具有惊人的机械性能。将低温凝胶与互穿网络策略相结合，可以制备出具有高机械性能和高离子分离性能的复合低温凝胶。通过将共价交联的合成网络与离子交联的藻酸盐网络组合，已经获得了高度可拉伸且极其坚韧的水凝胶。还报道了具有定制的筛目尺寸的IPN水凝胶。
Interpenetrating polymer network (IPN) hydrogels brought distinct benefits compared to single network hydrogels like more widely controllable physical properties, and (frequently) more efficient drug loading/release. However, IPN strategy is not sufficient to design hydrogels with enhanced mechanical properties required for regenerative medicine like replacement of natural cartilage or artificial cornea. Some of the novel techniques promoted last decade for the preparation of IPN hydrogels which fulfill these requirements are discussed in the review. Among them, "double network" strategy had a strong contribution in the development of a large variety of hydrogels with spectacular mechanical properties at water content up to 90 %. Using cryogelation in tandem with IPN strategy led to composite cryogels with high mechanical properties and high performances in separation processes of ionic species. Highly stretchable and extremely tough hydrogels have been obtained by combining a covalently cross-linked synthetic network with an ionically cross-linked alginate network. IPN hydrogels with tailored mesh size have been also reported.