New interpretation of arterial stiffening due to cigarette smoking using a structurally motivated constitutive model
New interpretation of arterial stiffening due to cigarette smoking using a structurally motivated constitutive model
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DOI：
10.1016/j.jbiomech.2011.01.032
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发表时间：
2011-04-07
影响因子：
2.4
通讯作者：
Humphrey, J. D.
中科院分区：
文献类型：
--
作者：
Eneyoldsen, M. S.;Henneberg, K. -A.;Humphrey, J. D.
吸烟是导致心血管疾病的最主要的自我伤害的危险因素：它会导致动脉硬化和严重的后遗症，包括动脉粥样硬化和腹主动脉瘤。这项工作提出了一个新的解释动脉硬化所造成的吸烟的基础上发表的数据为大鼠肺动脉。一个结构上的动机“四纤维家庭”的本构关系被用来拟合现有的双轴数据和相关的最佳拟合值的材料参数进行了估计，使用多元非线性回归。结果表明，吸烟引起的动脉硬化反映在弹性蛋白相关参数的一致增加，而且胶原蛋白相关参数的显着增加。也就是说，我们认为，动脉硬化由于吸烟似乎是各向同性的，这可能会允许更简单的现象学模型来捕捉这些影响，使用一个单一的硬化参数类似的方法在各向同性连续损伤力学。然而，迫切需要更详细的组织学信息以及更完整的全身动脉双轴力学数据。(C)2011爱思唯尔有限公司保留所有权利。
Cigarette smoking is the leading self-inflicted risk factor for cardiovascular diseases: it causes arterial stiffening with serious sequelea including atherosclerosis and abdominal aortic aneurysms. This work presents a new interpretation of arterial stiffening caused by smoking based on data published for rat pulmonary arteries. A structurally motivated "four fiber family" constitutive relation was used to fit the available biaxial data and associated best-fit values of material parameters were estimated using multivariate nonlinear regression. Results suggested that arterial stiffening caused by smoking was reflected by consistent increase in an elastin-associated parameter and moreover by marked increase in the collagen-associated parameters. That is, we suggest that arterial stiffening due to cigarette smoking appears to be isotropic, which may allow simpler phenomenological models to capture these effects using a single stiffening parameter similar to the approach in isotropic continuum damage mechanics. There is a pressing need, however, for more detailed histological information coupled with more complete biaxial mechanical data for a broader range of systemic arteries. (C) 2011 Elsevier Ltd. All rights reserved.