The carbohydrate metabolism of certain pathological overgrowths.
The carbohydrate metabolism of certain pathological overgrowths.
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DOI：
10.1042/bj0221289
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发表时间：
1928-01-01
影响因子：
4.1
通讯作者：
Crabtree, HG
中科院分区：
文献类型：
--
作者：
Crabtree, HG
使用Warburg的技术，已经检查了与细胞内病毒相关的一系列病变的碳水化合物代谢。在上皮明显增生的地方(如鸽子的鸡痘病变、小鸡的牛痘和人的疣)，发现一种活跃的新陈代谢，在性质和数量上都与恶性组织的特征相对应。当存在活跃的病毒但不伴有增殖时(如在狂犬病死亡的豚鼠的雨中)，没有发现偏离正常代谢的情况。鸡痘病变的代谢活性以图形显示，其大小与病变的发展或消退状态大致平行。Warburg发现，呼吸和糖酵解过程的大小和关系是恶性组织的特征，但不是恶性肿瘤特有的，而是病理性过度生长的共同特征。Rous鸡肉瘤的呼吸值有很大的变异性。Rous肉瘤细胞在注射无细胞滤液后第一次出现时，就具有完全生长的肿瘤的高代谢活性特征。
Using the technic of Warburg, the carbohydrate metabolism of a series of lesions, associated with intra-cellular viruses has been examined. Where epithelial hyperplasia is evident (as in lesions of fowl pox in pigeons, vaccinia in young chickens, and human warts) an active metabolism is found, corresponding in type to that characteristic of malignant tissue, both qualitatively and quantitatively. When an active virus is present but unaccompanied by hyperplasia (as in the rain of guinea pigs dying of rabies), no deviation is found from the normal metabolism. The metabolic activity of fowl pox lesions shown graphically, exhibits a rough parallelism in its magnitude to the state of development or regression of the lesion. It is suggested that the magnitude and relationship of the respiratory and glycolytic processes, found by Warburg to be characteristic of malignant tissues, are not specific for malignancy but are a common feature of pathological overgrowths. Great variability in values for respiration in the Rous chicken sarcoma are recorded. Rous sarcoma cells, on their first appearance after injection of cell-free filtrate, assume the high metabolic activity characteristic of the fully grown tumor.