Repeated partial hepatectomy as a promoting stimulus for carcinogenic response of liver to nitrosamines in rats.
Repeated partial hepatectomy as a promoting stimulus for carcinogenic response of liver to nitrosamines in rats.
复制标题
重复部分肝切除术作为大鼠肝脏对亚硝胺致癌反应的促进刺激。
作者：
A. Pound;L. Mcguire
单次腹腔注射前 24 小时进行部分肝切除术二甲基亚硝胺、二乙基亚硝胺或乙基甲基亚硝胺的剂量会增加大鼠肝脏中的致癌反应，这取决于肿瘤的数量和产生的“局灶性增殖”的数量。其次，在给予单次腹腔注射的大鼠中。给予二乙基亚硝胺剂量后，动物在给药后5周、10周和15周进行3次部分肝切除术，增加了肝脏的致癌反应。因此，重复部分肝切除术的刺激似乎充当肝癌发生的“促进剂”，也就是说，如果单剂量的二乙基亚硝胺被视为两阶段假说中的“引发剂”。
Partial hepatectomy 24 h before a single i.p. dose of dimethylnitrosamine, diethylnitrosamine or ethylmethylnitrosamine increased the carcinogenic response in the liver of rats as determined by the number of tumours and the number of "focal proliferations" produced. Secondly, in rats given a single i.p. dose of diethylnitrosamine, 3 partial hepatectomies 5, 10 and 15 weeks after dosing the animals increased the carcinogenic response in the liver. The stimulus of repeated partial hepatectomy therefore appears to act as a "promoting agent" for liver carcinogenesis, that is if the single dose of diethylnitrosamine is regarded as an "initiating agent" in the terms of the two-stage hypothesis.