SLEEP-PROMOTING EFFECTS OF ENDOGENOUS PYROGEN (INTERLEUKIN-1)
SLEEP-PROMOTING EFFECTS OF ENDOGENOUS PYROGEN (INTERLEUKIN-1)
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DOI：
10.1152/ajpregu.1984.246.6.r994
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发表时间：
1984-01-01
影响因子：
--
通讯作者：
CHEDID, L
中科院分区：
文献类型：
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作者：
KRUEGER, JM;WALTER, J;CHEDID, L
当注入兔侧脑室时，人内源性热原（EP）制剂可诱导剂量依赖性的慢波睡眠增加，同时伴有体温升高。将EP加热至70 ℃。C破坏其促睡眠和致热活性。茴香霉素（一种解热药）阻止EP升高体温，而不影响其促进睡眠的活性。静脉注射EP引起发热和短暂增加慢波睡眠，但未能引起长时间的增加慢波睡眠。EP的致眠活性明显不次于其致热活性。
When infused into the lateral cerebral ventricles of rabbits, human endogenous pyrogen (EP) preparations induced dose-dependent increases in slow-wave sleep concomitant with increasing body temperature. Heating EP to 70.degree. C destroyed its sleep-promoting and pyrogenic activity. Anisomycin (an antipyretic) prevented EP from increasing body temperature without affecting its sleep-promoting activity. I.v. injection of EP induced fever and transient increases in slow-wave sleep but failed to induce prolonged increases in slow-wave sleep. The somnogenic activity of EP evidently is not secondary to its pyrogenic activity.