Air pollution and hospitalization for venous thromboembolic disease in Chile
Air pollution and hospitalization for venous thromboembolic disease in Chile
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DOI：
10.1111/j.1538-7836.2010.03760.x
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发表时间：
2010-04-01
影响因子：
10.4
通讯作者：
Vidal, C. B.
中科院分区：
文献类型：
--
作者：
Dales, R. E.;Cakmak, S.;Vidal, C. B.
背景资料：环境空气污染是中风和心肌梗死的危险因素，可能是因为凝血功能的改变影响了动脉循环。空气污染是否会影响与外周静脉血栓形成相关的疾病，在很大程度上仍然未知。目的：确定空气污染和静脉血栓栓塞性疾病（VTE）之间的联系，在一般人群的样本。研究方法：时间序列分析被用来检验2001年至2005年期间圣地亚哥每日空气污染和静脉血栓栓塞住院率之间的关系。结果进行了调整的长期趋势，一周中的一天和平均每日湿度。结果：在540万人口中，平均每天有2.3人因静脉血栓栓塞入院。静脉疾病住院的相对风险（RR）[95%置信区间（CI）]的合并估计值为：1.07（1.05，1.09），58.4 p.p.b.臭氧（O-3）增加; 5.85 p.p.b.二氧化硫（SO2）增加1.08（1.03，1.12），二氧化氮（NO2）增加29.25 μ g/m3;平均空气动力学直径< 2.5 μ m的颗粒物（PM2.5）增加20.02 μ g/m3，1.05（1.03，1.06）。对于肺栓塞（PE），结果分别为：O-3为1.10（1.07，1.13）; SO2为1.05（1.02，1.08）; NO2为1.07（1.04，1.09）; PM2.5为1.05（1.03，1.06）。结论：空气污染似乎是静脉血栓形成和PE的危险因素，PE是一种具有显著病死率的疾病。
Background: Ambient air pollution is a risk factor for stroke and myocardial infarction, possibly because of alterations in coagulation that influence the arterial circulation. Whether air pollution influences diseases associated with peripheral venous thrombogenesis remains largely unknown. Objectives: To determine the association between air pollution and venous thromboembolic disease (VTE) in a sample of the general population. Methods: A time-series analysis was used to test the association between daily air pollution and VTE hospitalizations in Santiago between 2001 and 2005. Results were adjusted for long-term trends, day of the week and average daily humidex. Results: From a population of 5.4 million, there were, on average, 2.3 admissions for VTE per day. Pooled estimates of relative risk (RR) [95% confidence interval (CI)] of hospitalization for venous disease were: 1.07 (1.05, 1.09) for a 58.4 p.p.b. increase in ozone (O-3); 1.06 (1.02, 1.09) for a 5.85 p.p.b. increase in sulphur dioxide (SO2); 1.08 (1.03, 1.12) for a 29.25 mu g/m3 increase in nitrogen dioxide (NO2); and 1.05 (1.03, 1.06) for a 20.02 mu g/m3 increase in particulate matter < 2.5 mu m in mean aerodynamic diameter (PM2.5). For pulmonary embolism (PE) results were: 1.10 (1.07, 1.13) for O-3; 1.05 (1.02, 1.08) for SO2; 1.07 (1.04, 1.09) for NO2; and 1.05(1.03, 1.06) for PM2.5, respectively. Conclusion: Air pollution appears to be a risk factor for venous thrombosis and PE, a disease with a significant fatality rate.