MATERNAL PLASMA ANDROGENS IN EARLY HUMAN-PREGNANCY
MATERNAL PLASMA ANDROGENS IN EARLY HUMAN-PREGNANCY
复制标题
DOI：
10.1111/j.1471-0528.1980.tb04603.x
复制
发表时间：
1980-01-01
期刊：
影响因子：
--
通讯作者：
MANSFIELD, MD
中科院分区：
文献类型：
--
作者：
HARRISON, RF;MANSFIELD, MD
孕妇血浆睾酮、雄烯二酮和5α-双氢睾酮的平均水平是从妊娠4-16周采集的15名孕妇每周两次的血液样本中确定的。与未怀孕状态相比，这三种激素水平都有所提高。怀孕4-5周和7-8周的孕妇平均血浆睾酮水平有显著差异，而怀有男性和女性胎儿的妇女则不同。双胞胎妊娠期间雄烯二酮水平一直升高，从第15周开始，睾酮水平比平均值高出1SD以上。在流产的两名妇女中，类固醇水平后期下降。三名服用孕激素的女性的荷尔蒙水平在正常范围内。
Mean maternal plasma levels of testosterone, androstenedione, and 5 α‐dihydro‐testosterone were established from 4 to 16 weeks gestation from twice‐weekly blood samples taken from 15 pregnant women. All three hormone levels were raised when compared with the non‐pregnant state. There were significant differences in mean maternal plasma testosterone levels at 4 to 5 and 7 to 8 weeks gestation, when comparing women carrying male and female fetuses. Androstenedione levels in a twin pregnancy were increased throughout and testosterone levels were more than 1 SD above the mean from week 15. Steroid levels fell late in the two women who aborted. Hormone levels in three women being given progestogens were within normal limits.