Turing Pattern Formation without Diffusion
Turing Pattern Formation without Diffusion
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DOI：
10.1007/978-3-642-30870-3_42
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发表时间：
2012-06
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影响因子：
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通讯作者：
Shigeru Kondo
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文献类型：
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作者：
Shigeru Kondo
以斑马鱼的色素斑为实验系统，研究了皮肤斑的形成机理。最近的研究发现，两种类型的色素细胞，黑色素细胞和黄色素细胞之间的细胞相互作用，揭示了细胞和分子机制。有了这些数据，我们现在可以回答一个关键的问题，“这是一个图灵机制还是没有？”我们已经确定了色素细胞之间的三个相互作用的分子基础。所有这些都转移到细胞树突的尖端。尽管有许多理论生物学家的期望，但图案化机制中涉及的化学物质并没有扩散。然而，我们也发现，在不同的相互作用中，树突的长度是不同的，这使得产生“局部正反馈和长程负反馈”图灵斑图的条件成为可能。虽然它不包含“扩散”，但它可以被称为图灵机制。
Using the pigmentation pattern of zebrafish as the experimental system, we have been studying the mechanism of skin pattern formation. Recent findings of the cellular interactions among the two types of pigment cells, melanophores and xanthophores, are uncovering the cellular and molecular mechanisms. With these data, we now can answer the crucial question, “Is this a Turing mechanism or not?” We have identified the molecular basis of three interactions between the pigment cells. All of them are transferred at the tip of the dendrites of cells. In spite of the expectation of many theoretical biologists, there is no diffusion of the chemicals involved in the patterning mechanism. However, we also found that the lengths of the dendrites are different among the interactions, which makes it possible to generate the conditions of Turing pattern formation, “local positive feedback and long range negative feedback”. Although it does not contain “diffusion”, it may be appropriate to be called as a Turing mechanism.