Prognostic Factors of Patients with Spinal Chondrosarcoma: A Retrospective Analysis of 98 Consecutive Patients in a Single Center
Prognostic Factors of Patients with Spinal Chondrosarcoma: A Retrospective Analysis of 98 Consecutive Patients in a Single Center
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DOI：
10.1245/s10434-014-3745-z
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发表时间：
2014-10-01
影响因子：
3.7
通讯作者：
Xiao, Jianru
中科院分区：
文献类型：
--
作者：
Yin, Huabin;Zhou, Wang;Xiao, Jianru
脊椎软骨肉瘤（CHS）是相对罕见的，文献中关于这一主题的信息很少。本研究的目的是探讨可能影响脊柱CHS患者预后的因素，并进行单因素和多因素分析，以确定脊柱CHS复发、远处转移和生存的预后因素。单因素分析采用T检验、卡方检验和秩和检验，生存率采用Kaplan-Meier法。通过二元逻辑回归分析或考克斯回归分析对p值<0.1的因素进行多变量分析。p值<0.05有统计学意义。共纳入98例脊柱CHS患者。平均随访时间为49.7个月（范围6-178）。在我们中心的初次手术后，42例患者复发，而远处转移和死亡分别发生在24和32例。统计学分析表明，病理分级与远处转移密切相关，远处转移是影响总生存率的独立预后因素。全脊椎整块切除术可显著降低脊柱CHS患者的复发、远处转移和死亡风险，并可显著降低复发和远处转移的风险，同时提高脊柱CHS的总生存率。与病理分级III密切相关的远处转移是脊柱CHS总生存率的不良预后因素。
Chondrosarcoma (CHS) in the spine is relatively rare and minimal information has been published in the literature regarding this subject. The objective of our study was to discuss the factors that may affect outcomes of patients with spinal CHS.Univariate and multivariate analyses were performed to identify prognostic factors for recurrence, distant metastasis, and survival of spinal CHS. T test, chi (2) test and rank sum test were used to analyze a single factor for recurrence and metastasis, while survival rate was estimated using the Kaplan-Meier method. Factors with p values of a parts per thousand currency sign0.1 were subjected to multivariate analyses by binary logistic regression analyses or Cox regression analyses. p Values of a parts per thousand currency sign0.05 were considered statistically significant.A total of 98 patients with spinal CHS were included in the study. The mean follow-up period was 49.7 months (range 6-178). Recurrence was detected in 42 patients after initial surgery in our center, while distant metastasis and death occurred in 24 and 32 cases, respectively. The statistical analyses suggested that pathology grade III was closely related with distant metastasis which was an independent prognostic factor for overall survival. Total en bloc spondylectomy could significantly decrease the risk of recurrence, distant metastasis, and death of patients with spinal CHS.Total en bloc spondylectomy could significantly decrease the risk of recurrence and distant metastasis, and meanwhile improve overall survival of spinal CHS. Distant metastasis which was closely associated with pathology grade III was an adverse prognostic factor for overall survival of spinal CHS.