Morphometric grading of invasive ductal breast cancer. I. Thresholds for nuclear grade.
Morphometric grading of invasive ductal breast cancer. I. Thresholds for nuclear grade.
复制标题
侵入性导管乳腺癌的形态分级。 I.核等级的阈值。
DOI：
10.1038/bjc.1998.582
复制
发表时间：
1998-09
影响因子：
8.8
通讯作者：
Collan, Y
中科院分区：
文献类型：
--
作者：
Kronqvist, P;Kuopio, T;Collan, Y
我们分析了170例浸润性导管乳腺癌的组织学样本，从1988年至1991年的计算机核形态测量，以找到客观和定量的核分级阈值。基于反映疾病的存活和复发的Kaplan-Meier曲线和通过考克斯回归的单变量分析，确定与核大小和大小变化相关的特征的最佳阈值。在我们的材料中，平均随访时间为5年9个月，核轮廓面积（32 μ m2和47 μ m2），核直径（6.4 μ m和7.4 μ m）和平均最短核轴（4.8 μ m和6.4 μ m）的确定阈值最好地区分了有利，中间和不利的疾病过程的情况。在乳腺X线摄影和辅助治疗时代的材料中，发现平均最短核轴是一个重要的预后因素，其风险比（RR）仅超过肿瘤大小（RR分别为2.9和3.5倍）。结果表明，形态学分级标准可用于Bloom-Richardson分级和诺丁汉预后指数。
We analysed 170 histological samples of invasive ductal breast cancer from years 1988-91 by computerized nuclear morphometry, to find objective and quantitative thresholds for nuclear grade. Based on Kaplan-Meier curves reflecting survival and recurrence of disease and univariate analysis by Cox's regression, optimal thresholds were determined for features related to nuclear size and size variation. In our material, with mean follow-up time of 5 years 9 months, the determined thresholds for nuclear profile area (32 microm2 and 47 microm2), nuclear diameter (6.4 microm and 7.4 microm) and mean shortest nuclear axis (4.8 microm and 6.4 microm) best separated the cases with favourable, intermediate and unfavourable course of disease. In this material from the era of mammography and adjuvant therapy, the mean shortest nuclear axis was found to be a significant prognostic factor, with a risk ratio (RR) exceeded only by that of tumour size (RRs 2.9- and 3.5-fold respectively). The results suggest that morphometric grading criteria can be developed for application in Bloom-Richardson grading and in the Nottingham Prognostic Index.