LONGITUDINAL-STUDY OF PLATELET ANGIOTENSIN-II BINDING IN HUMAN-PREGNANCY
LONGITUDINAL-STUDY OF PLATELET ANGIOTENSIN-II BINDING IN HUMAN-PREGNANCY
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DOI：
10.1042/cs0820377
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发表时间：
1992-04-01
期刊：
影响因子：
6
通讯作者：
SYMONDS, EM
中科院分区：
文献类型：
--
作者：
BAKER, PN;PIPKIN, FB;SYMONDS, EM
1. 对30例妊娠期和产褥期妇女的血小板血管紧张素II结合率、循环血管紧张素II水平、血浆肾素底物和血浆肾素浓度进行了纵向研究. 孕11 ~ 18周血小板血管紧张素Ⅱ结合率显著下降（P < 0.01）。 血小板血管紧张素Ⅱ结合率在产后无明显变化，产后6周较孕36周显著升高（P < 0.01）。 产后6至12周没有进一步显着变化，妊娠队列产后6和12周的血小板血管紧张素II结合率与非妊娠女性接近。 这些变化与妊娠期对血管紧张素II的升压反应性相似。 妊娠期血浆血管紧张素II、血浆肾素底物和血浆肾素浓度均显著高于产褥期（P < 0.001）。 妊娠期间血浆血管紧张素II浓度和血浆肾素浓度无明显变化，但血浆肾素底物水平升高. 妊娠期血小板血管紧张素Ⅱ结合率与血浆血管紧张素Ⅱ浓度（P < 0.01）、血浆肾素底物（P < 0.01）及血浆肾素浓度（P <0.001）呈显著负相关< 0 >。 这些数据表明，下调血小板血管紧张素II结合的组分的肾素-血管紧张素系统属于妊娠。 我们目前正在研究血小板和血管血管紧张素结合位点之间的平行性。 如果这一点得到证实，妊娠期血小板血管紧张素II结合的研究可能具有与妊娠期高血压疾病相关的基本生理和临床意义。
1. Platelet angiotensin II binding, circulating angiotensin II levels, plasma renin substrate and plasma renin concentration were measured in a longitudinal study of 30 women during pregnancy and the puerperium.2. There was a significant fall in platelet angiotensin II binding from 11 weeks gestation to 18 weeks gestation (P < 0.01). There were no further significant changes in platelet angiotensin II binding until after delivery, a significant rise in platelet angiotensin II binding being found at 6 weeks post partum as compared with at 36 weeks gestation (P < 0.01). There was no further significant change from 6 to 12 weeks post partum, and platelet angiotensin II binding at 6 and 12 weeks post partum in the pregnant cohort approximated to that in nonpregnant women. These changes parallel those known to occur in pressor responsiveness to angiotensin II in pregnancy.3. Plasma angiotensin II concentration, plasma renin substrate and plasma renin concentration were all significantly higher during pregnancy than in the puerperium (P < 0.001). There were no significant changes during pregnancy in plasma angiotensin II concentration or plasma renin concentration, although plasma renin substrate rose throughout.4. Significant inverse correlations between platelet angiotensin II binding and plasma angiotensin II concentration (P < 0.01), plasma renin substrate (P < 0.01) and plasma renin concentration (P < 0 > 001) were found during pregnancy. These data suggest that down-regulation of platelet angiotensin II binding by the components of the renin-angiotensin system pertains in pregnancy.5. We are currently investigating parallelism between platelet and vascular angiotensin-binding sites. If such is confirmed, studies of platelet angiotensin II binding in pregnancy may be of both basic physiological and clinical interest in relation to the hypertensive diseases of pregnancy.