A cause-specific hazard rate analysis of prognostic factors among 877 adults who received primary orthotopic liver transplantation
A cause-specific hazard rate analysis of prognostic factors among 877 adults who received primary orthotopic liver transplantation
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DOI：
10.1097/01.tp.0000269090.90068.0f
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发表时间：
2007-07-27
期刊：
影响因子：
6.2
通讯作者：
Tzakis, Andreas G.
中科院分区：
文献类型：
--
作者：
Gaynor, Jeffrey J.;Moon, Jang I.;Tzakis, Andreas G.
背景在原位肝移植（奥尔特）中，存在移植物功能衰竭（GF）和死亡（DFG）的不同原因。一种故障类型的预后因素可能与其他类型的预测因素明显不同，这些关系的准确描述可能会更清楚地解释每个因素的重要性。采用考克斯逐步回归对1996-2004年间877例采用他克莫司+类固醇作为免疫抑制剂接受原位奥尔特的成人患者进行多变量病因特异性风险（CSH）率分析。年龄较大的供体（P=0.004）意味着更大的原发性功能障碍GF，而原发性硬化性胆管炎（PSC; P=0.0002）意味着更大的血管血栓形成GF。复发性非恶性肝病GF在丙型肝炎病毒感染者中较高（P
Background. In orthotopic liver transplantation (OLT) distinct causes of graft failure (GF) and death with a functioning graft (DFG) exist. Prognostic factors for one failure type may be distinctly different from those predictive of other types, and an accurate portrayal of these relationships may more clearly explain each factor's importance.Methods. A multivariable cause-specific hazard (CSH) rate analysis using Cox stepwise regression was performed among 877 adults who received primary OLT during 1996-2004 with tacrolimus+steroids as immunosuppression.Results. Older donor age (P=0.004) implied greater primary dysfunction GF, while primary sclerosing cholangitis (PSC; P=0.0002) implied greater vascular thrombosis GF. Recurrent nonmalignant liver disease GF was higher among hepatitis C virus patients (P