Effects of zoledronate versus placebo on spine bone mineral density and microarchitecture assessed by the trabecular bone score in postmenopausal women with osteoporosis: A three-year study
Effects of zoledronate versus placebo on spine bone mineral density and microarchitecture assessed by the trabecular bone score in postmenopausal women with osteoporosis: A three-year study
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DOI：
10.1002/jbmr.1775
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发表时间：
2013-03-01
影响因子：
6.2
通讯作者：
Lippuner, Kurt
中科院分区：
文献类型：
--
作者：
Popp, Albrecht W.;Guler, Sabina;Lippuner, Kurt
骨小梁评分(TBS)是根据腰椎(LS)前后双能X射线吸收法(DXA)扫描计算出的骨微结构纹理指数，可预测骨折风险，独立于骨密度(BMD)。本研究的目的是比较每年静脉注射唑来膦酸盐(ZOL)和安慰剂(PLB)对绝经后骨质疏松症妇女LS、BMD和TBS的影响。对瑞士伯尔尼大学医院骨质疏松科招募的107名患者的TBS变化进行了评估，这些患者包括在Horizon试验中。所有受试者都接受了充足的钙和维生素D3。这些患者被随机分配到ZOL(n=54)或PLB(n=53)治疗3年，在基线和治疗开始后6、12、24和36个月用DXA和TBS Insight(v1.9)评估BMD。基线特征(平均+/-SD)在以下方面相似：年龄76.8+/-5.0岁；体重指数24.5+/-3.6 kg/m2；TBS，1.178+/-0.1，但LS T-Score(ZOL2.9+/-1.5vsPLB2.1+/-1.5)。在所有时间点，ZOL组的腰椎骨密度变化均显著大于PLB组(p
The trabecular bone score (TBS) is an index of bone microarchitectural texture calculated from anteroposterior dual-energy X-ray absorptiometry (DXA) scans of the lumbar spine (LS) that predicts fracture risk, independent of bone mineral density (BMD). The aim of this study was to compare the effects of yearly intravenous zoledronate (ZOL) versus placebo (PLB) on LS BMD and TBS in postmenopausal women with osteoporosis. Changes in TBS were assessed in the subset of 107 patients recruited at the Department of Osteoporosis of the University Hospital of Berne, Switzerland, who were included in the HORIZON trial. All subjects received adequate calcium and vitamin D3. In these patients randomly assigned to either ZOL (n=54) or PLB (n=53) for 3 years, BMD was measured by DXA and TBS assessed by TBS iNsight (v1.9) at baseline and 6, 12, 24, and 36 months after treatment initiation. Baseline characteristics (mean +/- SD) were similar between groups in terms of age, 76.8 +/- 5.0 years; body mass index (BMI), 24.5 +/- 3.6kg/m2; TBS, 1.178 +/- 0.1 but for LS T-score (ZOL2.9 +/- 1.5 versus PLB2.1 +/- 1.5). Changes in LS BMD were significantly greater with ZOL than with PLB at all time points (p