The stroma reaction myofibroblast:: a key player in the control of tumor cell behavior
The stroma reaction myofibroblast:: a key player in the control of tumor cell behavior
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DOI：
10.1387/ijdb.041802ad
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发表时间：
2004-01-01
影响因子：
0.7
通讯作者：
Gabbiani, C
中科院分区：
文献类型：
--
作者：
Desmoulière, A;Guyot, C;Gabbiani, C
上皮细胞和间充质细胞之间的协作对胚胎发育至关重要，并可能在伤口愈合和肿瘤进展等病理现象中发挥重要作用。众所周知，许多上皮性肿瘤的特点是结缔组织细胞和细胞外物质局部堆积，这种现象被称为间质反应。间质反应的细胞成分之一是肌成纤维细胞，它是一种受调节的成纤维细胞，已经获得了新表达α-平滑肌肌动蛋白的能力，α-平滑肌肌动蛋白是血管平滑肌细胞中典型的肌动蛋白亚型，并合成大量的胶原和其他细胞外基质成分。目前普遍认为，肌成纤维细胞是创面愈合和纤维化发展过程中结缔组织重塑的关键细胞。肌成纤维细胞能够重塑结缔组织，也可以与上皮细胞和其他结缔组织细胞相互作用，从而可能控制肿瘤侵袭和血管生成等现象。在这篇综述中，我们讨论了肌成纤维细胞在纤维化和恶性疾病中的进化机制，以及肌成纤维细胞与其他细胞的相互作用，以控制肿瘤的进展。在此基础上，我们认为肌成纤维细胞可能是抗肿瘤治疗的一个新的重要靶点。
The cooperation between epithelial and mesenchymal cells is essential for embryonic development and probably plays an important role in pathological phenomena such as wound healing and tumor progression. It is well known that many epithelial tumors are characterized by the local accumulation of connective tissue cells and extracellular material; this phenomenon has been called the stroma reaction. One of the cellular components of the stroma reaction is the myofibroblast, a modulated fibroblast which has acquired the capacity to neoexpress alpha-smooth muscle actin, the actin isoform typical of vascular smooth muscle cells, and to synthesize important amounts of collagen and other extracellular matrix components. It is now well accepted that the myofibroblast is a key cell for the connective tissue remodeling which takes place during wound healing and fibrosis development. Myofibrobasts are capable of remodeling connective tissue but also interact with epithelial cells and other connective tissue cells and may thus control such phenomena as tumor invasion and angiogenesis. In this review we discuss the mechanisms of myofibroblast evolution during fibrotic and malignant conditions and the interaction of myofibroblasts with other cells in order to control tumor progression. On this basis we suggest that the myofibroblast may represent a new important target of antitumor therapy.