Demography of dietary restriction and death in Drosophila
Demography of dietary restriction and death in Drosophila
复制标题
DOI：
10.1126/science.1086016
复制
发表时间：
2003-09-19
期刊：
影响因子：
56.9
通讯作者：
Partridge, L
中科院分区：
文献类型：
--
作者：
Mair, W;Goymer, P;Partridge, L
饮食限制（DR）可以延长从酵母到哺乳动物等生物体的寿命，大概是通过减缓衰老相关损伤的积累来实现的。在这里，我们表明，在果蝇中，DR 完全通过降低短期死亡风险来延长寿命。在任何年龄首次施用 DR 两天后，之前完全喂食的果蝇死亡的可能性并不比已接受长期 DR 的同龄果蝇更高。哺乳动物的 DR 还可以降低短期死亡风险，因此在任何年龄发起 DR 都可以完全逆转死亡率。
Dietary restriction (DR) increases life-span in organisms from yeast to mammals, presumably by slowing the accumulation of aging-related damage. Here we show that in Drosophila, DR extends life-span entirely by reducing the short-term risk of death. Two days after the application of DR at any age for the first time, previously fully fed flies are no more likely to die than flies of the same age that have been subjected to long-term DR. DR of mammals may also reduce short-term risk of death, and hence DR instigated at any age could generate a full reversal of mortality.