Safety and Tolerability of Clofazimine in a Cohort of Children With Odontogenic Mycobacterium abscessus Infection
Safety and Tolerability of Clofazimine in a Cohort of Children With Odontogenic Mycobacterium abscessus Infection
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DOI：
10.1093/jpids/piz049
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发表时间：
2020-09-01
影响因子：
3.2
通讯作者：
Arrieta, Antonio
中科院分区：
文献类型：
--
作者：
Adler-Shohet, Felice C.;Singh, Jasjit;Arrieta, Antonio
氯法齐明具有很好的体外抗分枝杆菌活性，但其应用的报道，特别是在儿童中的报道有限。在这项研究中，在牙源性分枝杆菌感染爆发期间，27名儿童接受了氯法齐明治疗，作为多药治疗方案的一部分，似乎耐受性良好。
Mycobacterium abscessus infections can be challenging to treat. Clofazimine has excellent in vitro activity against M abscessus, but reports of its use, particularly in children, have been limited. In this study, clofazimine was given to 27 children during an outbreak of odontogenic mycobacterial infections and seemed to be well tolerated as part of a multidrug regimen.