Oxyhemoglobin Changes During Cognitive Rehabilitation After Traumatic Brain Injury Using Near Infrared Spectroscopy
Oxyhemoglobin Changes During Cognitive Rehabilitation After Traumatic Brain Injury Using Near Infrared Spectroscopy
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DOI：
10.2176/nmc.53.299
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发表时间：
2013-05-01
影响因子：
1.9
通讯作者：
Kabasawa, Hidehiro
中科院分区：
文献类型：
--
作者：
Hibino, Shin;Mase, Mitsuhito;Kabasawa, Hidehiro
为了调查认知康复任务的大脑反应，在名古屋市康复中心执行的 9 项认知康复任务中，使用功能性近红外光谱 (fNIRS) 比较了 9 名创伤性脑损伤 (TBI) 后认知障碍患者和 47 名健康对照者的氧合血红蛋白变化。四十七个测量通道被放置在额叶到颞叶皮质上，并被组织成七个通道区域。氧合血红蛋白的变化根据静息状态下的平均氧合血红蛋白值进行标准化，并在整个任务中进行整合。使用双边 Mann-Whitney U 检验对 TBI 患者和对照之间的差异进行统计分析。对照组和 TBI 患者额叶外侧区域的氧合血红蛋白变化均较高。对于大多数训练任务，TBI 患者的内侧额叶区域的氧合血红蛋白变化往往高于对照组，并且在内侧额叶区域的两项任务中观察到显着差异 (p < 0.05)。与对照组相比，TBI 患者的不同区域在任务过程中被激活。 fNIRS 测量可用于评估 TBI 患者康复任务期间神经元活动的变化。
To investigate cerebral reactions to cognitive rehabilitation tasks, oxyhemoglobin changes were compared in 9 patients with cognitive impairments after traumatic brain injury (TBI) and 47 healthy controls using functional near infrared spectroscopy (fNIRS) during nine cognitive rehabilitation tasks employed at Nagoya City Rehabilitation Center. Forty-seven measurement channels were placed on the frontal to temporal cortices, and organized into seven channel regions. Oxyhemoglobin changes were normalized based on the mean oxyhemoglobin value at the resting state, and integrated throughout a task. Statistical analyses of the differences between the TBI patients and controls were performed with the two-sided Mann-Whitney U test. Oxyhemoglobin changes were high for both controls and TBI patients in the lateral frontal regions. Oxyhemoglobin changes in TBI patients tended to be higher than controls in the medial frontal regions for most training tasks, and significant differences (p < 0.05) were seen for two tasks in the medial frontal regions. Different regions were activated during the tasks in TBI patients compared to controls. fNIRS measurement is useful in the evaluation of changes of neuronal activities during rehabilitation tasks in TBI patients.