Eosinopenia, in Chronic Spontaneous Urticaria, Is Associated with High Disease Activity, Autoimmunity, and Poor Response to Treatment
Eosinopenia, in Chronic Spontaneous Urticaria, Is Associated with High Disease Activity, Autoimmunity, and Poor Response to Treatment
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DOI：
10.1016/j.jaip.2019.08.025
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发表时间：
2020-01-01
影响因子：
9.4
通讯作者：
Maurer, Marcus
中科院分区：
文献类型：
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作者：
Kolkhir, Pavel;Church, Martin K.;Maurer, Marcus
背景技术背景：慢性自发性荨麻疹（CSU）的特征是皮肤肥大细胞脱颗粒，嗜碱性粒细胞和嗜酸性粒细胞流入受影响的皮肤部位。血液中的碱性粒细胞减少症已被链接到严重的抗组胺药耐药的CSU和IIb型自身免疫，而嗜酸性粒细胞在CSU的作用在很大程度上是unknown.OBJECTIVE：分析数据从1613例CSU患者从2个中心研究的患病率，作用，和相关性嗜酸性粒细胞减少症在CSU.METHODS：外周血嗜酸性粒细胞和嗜碱性粒细胞计数进行了测定自动血液分析仪。患者档案进行筛选的临床特征，实验室检查，自体血清皮肤试验，血清诱导的嗜碱性粒细胞组胺释放测定，并响应第二代H-1-抗组胺药和omalizumab.RESULTS：百分之十的CSU患者有嗜酸性粒细胞减少症。嗜酸粒细胞减少与女性、疾病活动度高、自体血清皮肤试验和嗜碱性粒细胞组胺释放试验阳性、总IgE低、C反应蛋白和IgG抗甲状腺过氧化物酶水平高有关（P
BACKGROUND: Chronic spontaneous urticaria (CSU) is characterized by the degranulation of skin mast cells and the influx of basophils and eosinophils to affected skin sites. Blood basopenia has been linked to severe antihistamine-resistant CSU and type IIb autoimmunity, whereas the role of eosinophils in CSU is largely unknown.OBJECTIVE: To analyze data from 1613 patients with CSU from 2 centers to study the prevalence, role, and relevance of eosinopenia in CSU.METHODS: Peripheral blood eosinophil and basophil counts were measured by automated hematology analyzers. Patient files were screened for clinical characteristics, results of laboratory tests, the autologous serum skin test, the serum-induced basophil histamine release assay, and response to second-generation H-1-antihistamines and omalizumab.RESULTS: Ten percent of patients with CSU had eosinopenia. Eosinopenia was associated with the female sex, high disease activity, autologous serum skin test and basophil histamine release assay positivity, low total IgE, and high levels of C-reactive protein and IgG-antithyroperoxidase (P