ANALYSIS OF INSERTIONS DELETIONS IN PROTEIN STRUCTURES
ANALYSIS OF INSERTIONS DELETIONS IN PROTEIN STRUCTURES
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DOI：
10.1016/0022-2836(92)91008-d
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发表时间：
1992-03-20
影响因子：
5.6
通讯作者：
ARGOS, P
中科院分区：
文献类型：
--
作者：
PASCARELLA, S;ARGOS, P
报道了基于蛋白质三级结构的多序列比对数据库中插入和缺失（indels）的分析。插入缺失优选短的（1至5个残基）。它们之间的平均间插序列长度与成对比对中残基同一性的百分比显示出指数行为，这表明了一个随机过程，使得祖先结构中的几乎每个环都是进化过程中indel的可能目标。结果还表明，蛋白质结构容纳的插入缺失的平均大小的限制。优选的插入/缺失构象是反向转角和卷曲，插入/缺失边缘（N-和C-末端侧）处的优选构象也是如此。观察到螺旋和链中断是非常罕见的事件。
An analysis of insertions and deletions (indels) occurring in a databank of multiple sequence alignments based on protein tertiary structure is reported. Indels prefer to be short (1 to 5 residues). The average intervening sequence length between themversusthe percentage of residue identity in pairwise alignments shows an exponential behaviour, suggesting a stochastic process such that nearly every loop in an ancestral structure is a possible target for indels during evolution. The results also suggest a limit to the average size of indels accommodated by protein structures. The preferred indel conformations are reverse turn and coil as are the preferred conformations at the indel edges (N- and C-terminal sides). Interruptions in helices and strands were observed as very rare events.