Inflammatory cell types and clinical features of interstitial cystitis.
Inflammatory cell types and clinical features of interstitial cystitis.
复制标题
炎症细胞类型和间质性膀胱炎的临床特征。
DOI：
10.1097/00005392-199709000-00025
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Dabbs,DJ
中科院分区：
文献类型：
--
作者：
Erickson,DR;Belchis,DA;Dabbs,DJ
PurposeWe测试是否类型的炎症细胞上看到的膀胱活检组织与其他临床特征和尿标记物的间质性膀胱炎mistaken.Materials和Methods膀胱活检组织从30间质性膀胱炎患者进行了评估免疫组化染色的T细胞，B细胞，巨噬细胞和人类白细胞抗原DR阳性细胞。这些研究结果进行了测试与间质性膀胱炎的临床特征和尿标记物的关联使用α = 0.01，因为多个测试performed.ResultsOverall严重程度的炎症显着相关的年龄在症状发作，症状缓解后膀胱扩张和尿白细胞介素-6水平。严重炎症患者在麻醉下有膀胱容量变小的趋势，膀胱血管和粘膜裂缝增加，尿MUC-1糖蛋白水平降低，没有腹胀症状。B细胞染色与严重炎症、腹胀后症状缓解和无腹胀症状显著相关。T细胞染色与严重炎症和症状出现时的年龄显着相关。人类白细胞抗原-DR染色具有症状的趋势，包括存在腹胀、持续排尿欲望和无烧灼感。巨噬细胞染色没有与任何功能测试在α = 0.05 level.ConclusionsInterstitial膀胱炎患者严重炎症有不同的年龄，治疗反应和尿标记物水平比那些轻度炎症。这些结果表明，2个患者组具有不同的基础病理生理学。T和B细胞染色的显著相关性与总体炎症的相关性相似。
PurposeWe tested whether the types of inflammatory cells seen on bladder biopsies were associated with other clinical features and urinary markers of interstitial cystitis.Materials and MethodsBladder biopsies from 30 interstitial cystitis patients were evaluated by immunohistochemical staining for T cells, B cells, macrophages and human leukocyte antigen-DR positive cells. These findings were tested for associations with clinical features and urinary markers of interstitial cystitis using alpha = 0.01 because multiple tests were performed.ResultsOverall severity of inflammation was significantly associated with age at symptom onset, symptom relief after bladder distention and urinary interleukin-6 levels. Patients with severe inflammation had trends toward smaller bladder capacity under anesthesia, increased bladder vascularity and mucosal cracks, lower urinary MUC-1 glycoproten levels and absence of bloating as a symptom. B cell staining was significantly associated with severe inflammation, symptom relief after distention and absence of bloating as a symptom. T cell staining was significantly associated with severe inflammation and age at symptom onset. Human leukocyte antigen-DR staining had trends with symptoms, including presence of bloating, constant urge to void and absence of burning. Macrophage staining did not associate with any features tested at the alpha = 0.05 level.ConclusionsInterstitial cystitis patients with severe inflammation have different age, treatment response and urinary marker levels than those with mild inflammation. These findings suggest that the 2 patient groups have different underlying pathophysiologies. The significant associations for T and B cell staining were similar to those for overall inflammation.