Anatomical mapping of white matter hyperintensities (WMH) - Exploring the relationships between periventricular WMH, deep WMH, and total WMH burden
Anatomical mapping of white matter hyperintensities (WMH) - Exploring the relationships between periventricular WMH, deep WMH, and total WMH burden
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DOI：
10.1161/01.str.0000150668.58689.f2
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发表时间：
2005-01-01
期刊：
影响因子：
8.3
通讯作者：
Jagust, WJ
中科院分区：
文献类型：
--
作者：
DeCarli, C;Fletcher, E;Jagust, WJ
背景和目的-MRI分割和标测技术被用于评估支持脑室周围白色高信号（PVWMH）和深部WMH（DWMH）之间分类区别的证据。定性MRI研究通常根据解剖定位将WMH分为2类。单独的病理生理学和行为后果通常归因于这2类WMH。然而，证据来支持这些经验的区别还没有被严格searched. Methods-MRI分析55名受试者包括量化的WMH体积，映射到一个共同的解剖图像，和空间定位的每个WMH体素。然后根据与侧脑室的距离和相关性将WMH位置分为PVWMH和DWMH，并确定总WMH体积。结果PVWMH和DWMH与总WMH高度相关（R-2>0.95），且PVWMH和DWMH之间高度相关（R-2>0.87）。所有WMH的映射显示从周围的中央脑脊液空间到更远的大脑白色matter随着WMH volume. Conclusion PVWMH，DWMH，总WMH是高度相关的。此外，空间分析未能确定不同的亚群PVWMH和DWMH。这些结果表明，PVWMH和DWMH之间的分类区别可能是任意的，关于PVWMH和DWMH的因果因素或行为之间的个体关系的结论可能更准确地反映总WMH体积关系。
Background and Purpose-MRI segmentation and mapping techniques were used to assess evidence in support of categorical distinctions between periventricular white matter hyperintensities (PVWMH) and deep WMH (DWMH). Qualitative MRI studies generally identify 2 categories of WMH on the basis of anatomical localization. Separate pathophysiologies and behavioral consequences are often attributed to these 2 classes of WMH. However, evidence to support these empirical distinctions has not been rigorously sought.Methods-MRI analysis of 55 subjects included quantification of WMH volume, mapping onto a common anatomical image, and spatial localization of each WMH voxel. WMH locations were then divided into PVWMH and DWMH on the basis of distance from the lateral ventricles and correlations, with total WMH volume determined. Periventricular distance histograms of WMH voxels were also calculated.Results-PVWMH and DWMH were highly correlated with total WMH (R-2>0.95) and with each other (R-2>0.87). Mapping of all WMH revealed smooth expansion from around central cerebrospinal fluid spaces into more distal cerebral white matter with increasing WMH volume.Conclusion-PVWMH, DWMH, and total WMH are highly correlated with each other. Moreover, spatial analysis failed to identify distinct subpopulations for PVWMH and DWMH. These results suggest that categorical distinctions between PVWMH and DWMH may be arbitrary, and conclusions regarding individual relationships between causal factors or behavior for PVWMH and DWMH may more accurately reflect total WMH volume relationships.