Plasma nitrite response and arterial reactivity differentiate vascular health and performance
Plasma nitrite response and arterial reactivity differentiate vascular health and performance
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DOI：
10.1016/j.niox.2009.01.002
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发表时间：
2009-06-01
影响因子：
3.9
通讯作者：
Annex, Brian H.
中科院分区：
文献类型：
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作者：
Allen, Jason D.;Miller, Elizabeth M.;Annex, Brian H.
NO 对于内皮功能和血管健康至关重要。血浆亚硝酸盐 (NO2-) 是 NO 的主要氧化产物，已被证明可以反映 eNOS 活性的变化。我们假设，随着血管疾病严重程度的增加，血浆 NO2- 对体育锻炼应激的反应以及生理内皮功能将会降低。受试者组为： (a) 有危险因素但无血管疾病 (1117)； (b) 不伴有血管疾病的 2 型糖尿病 (DM)； (c) 诊断出外周动脉疾病（PAD）； (d) DM + PAD。在休息时和最大运动后 10 分钟抽取静脉血。通过还原化学发光分析血浆样品。在前臂闭塞 (BAFMD) 之前、期间和之后 5 分钟对肱骨直径进行成像。各组之间的静息血浆 NO2- 或 BA 直径没有差异。 PAD 组的年龄调整 BAFMD 反应较低（p
NO is crucial for endothelial function and vascular health. Plasma nitrite (NO2-) is the main oxidation product of NO and has been shown to reflect changes in eNOS activity. We hypothesized that plasma NO2- response to physical exercise stress along with physiological endothelial function would be reduced with increasing severity of vascular disease. Subject groups were: (a) risk factors but no vascular disease (1117); (b) Type 2 diabetes with no vascular disease (DM); (c) diagnosed peripheral arterial disease (PAD); and (d) DM + PAD. Venous blood was drawn at rest and 10 min following maximal exercise. Plasma Samples were analyzed by reductive chemiluminescence. Brachial diameters were imaged prior to, during and following 5 min of forearm occlusion (BAFMD). There were no differences in resting plasma NO2- or BA diameters between groups. The PAD groups had lower age adjusted BAFMD responses (p