Impaired oxidative balance and association of blood glucose, insulin and HOMA-IR index in migraine.
Impaired oxidative balance and association of blood glucose, insulin and HOMA-IR index in migraine.
复制标题
偏头痛中氧化平衡受损以及血糖、胰岛素和 HOMA-IR 指数的关联。
DOI：
10.11613/bm.2011.023
复制
发表时间：
2011
期刊：
影响因子：
3.3
通讯作者：
G. Aykal
中科院分区：
文献类型：
--
作者：
N. Yılmaz;O. Aydin;A. Yeğin;A. Tiltak;E. Eren;G. Aykal
引言
糖代谢和偏头痛发生之间的关系的本质还没有被准确地阐明。本研究旨在探讨偏头痛患者氧化/抗氧化平衡状态及其与糖代谢的关系，以期对偏头痛的氧化机制有新的认识。
材料和方法
60名偏头痛患者和46名对照受试者参与了这项研究。除检测胰岛素和HOMA-IR指数外，还检测两组的氧化应激指数、总氧化剂和抗氧化状态。
结果
偏头痛患者的HOMA-IR指数显著增强(P=0.038)；与对照组相比，患者的氧化应激指数和总氧化状态也更高(P<；0.001)。
结论
这项初步研究表明，偏头痛患者的氧化/抗氧化平衡向氧化状态转变。较高的总氧化状态和HOMA-IR指数可能在偏头痛的潜在早期发病机制中起作用。
INTRODUCTION
The nature of the relationship between glucose metabolism and occurrence of migraine has not been elucidated precisely. This study investigated the status of oxidative/antioxidative balance and its relationship with the glucose metabolism in migraineurs to get new points of view for the underlying oxidative mechanisms.
MATERIALS AND METHODS
Sixty migraineurs and 46 control subjects were included in the study. Oxidative stress index, total oxidant and antioxidant status of both groups were examined in addition to the insulin and HOMA-IR index levels.
RESULTS
HOMA-IR index was significantly enhanced in migraineurs (P = 0.038); similarly oxidative stress index and total oxidant status were higher in patients compared to the controls (P < 0.001 for both).
CONCLUSION
This preliminary study shows that oxidative/antioxidative balance shifts towards the oxidative status in migraine. Higher total oxidant status and elevated HOMA-IR index might play a role in the potential early pathogenesis for migraine.