Radical trifluoromethylation of ketone Li enolates
Radical trifluoromethylation of ketone Li enolates
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DOI：
10.1016/j.tet.2006.03.115
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发表时间：
2006-07-24
期刊：
影响因子：
2.1
通讯作者：
Mikami, Koichi
中科院分区：
文献类型：
--
作者：
Itoh, Yoshimitsu;Mikami, Koichi
一般认为，由于α - cf3产物脱氟，高碱性Li烯醇化物不能作为自由基三氟甲基化的底物。然而，Li烯醇化物实际上可以用于自由基三氟甲基化。反应速度极快，最短反应时间仅为1 s左右。(c) 2006 Elsevier Ltd.版权所有。
It has generally been believed that highly basic Li enolates cannot be applied as substrates for radical trifluoromethylation due to defluorination of the alpha-CF3 product. However, Li enolates can be in fact employed for radical trifluoromethylation. Moreover, the reaction is extremely fast and the minimum reaction time is only similar to 1 s. (c) 2006 Elsevier Ltd. All rights reserved.