2015 Japanese Society for Dialysis Therapy: Guidelines for Renal Anemia in Chronic Kidney Disease
2015 Japanese Society for Dialysis Therapy: Guidelines for Renal Anemia in Chronic Kidney Disease
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2015 年日本透析治疗学会：慢性肾脏病肾性贫血指南
作者：
Hiroyasu Yamamoto;S. Nishi;T. Tomo;I. Masakane;K. Saito;M. Nangaku;M. Hattori;Takahiro Suzuki;S. Morita;A. Ashida;Yasuhiko Ito;T. Kuragano;Y. Komatsu;K. Sakai;Y. Tsubakihara;K. Tsuruya;Terumasa Hayashi;H. Hirakata;H. Honda
肾性贫血是慢性肾脏疾病的并发症。需要肾性贫血患者安全有效的治疗指南。日本透析治疗学会（JSDT）于2004年发布了慢性血液透析患者肾性贫血治疗指南，并于2008年发布了血液透析、腹膜透析、透析前和儿科患者肾性贫血治疗指南。这两篇出版物为临床实践问题提供了极好的指导，包括肾性贫血的定义和诊断、开始治疗的标准、目标血红蛋白水平、补铁治疗、输血和副作用。该指南显著改善了日本肾性贫血的治疗。然而，自2008年以来，许多研究已经评估了肾性贫血的治疗，现在可以使用红细胞生成刺激剂（ESA）。因此，JSDT执行委员会决定，现在是时候修订指南，使其更适合日本慢性肾脏病患者的情况。这是JSDT发布的肾性贫血指南的第三版。目的是通过治疗肾性贫血来改善慢性肾脏病患者的预后，包括肾移植后。本指南的预期使用者是从事慢性肾脏疾病治疗的所有医疗保健专业人员。关于成人透析和透析前患者的治疗，在第2章（目标Hb水平和开始肾性贫血治疗的标准）和第4章（铁状态和铁治疗的评价）中回答临床问题时提供了声明和评论。此外，在第1章（肾性贫血的诊断）、第3章（ESA的给药-给药途径和剂量）、第5章（ESA低反应性）、第6章（ESA的副作用和伴随症状）和第7章（红细胞输注）中提供了基本信息以及关键问题。此外，第8章和第9章分别讨论了儿科患者和肾移植后患者的治疗。
Renal anemia is a complication of chronic kidney disease. Guidelines for safe and effective treatment in patients with renal anemia are needed. The Japanese Society for Dialysis Therapy (JSDT) published guidelines for the treatment of renal anemia in chronic hemodialysis patients in 2004 and in hemodialysis, peritoneal dialysis, predialysis, and pediatric patients in 2008. These two publications provide excellent guidance with respect to clinical practice issues, including the definition and diagnosis of renal anemia, the criteria for the initiation of treatment, target hemoglobin levels, iron supplementation therapy, blood transfusion, and side effects. The guidelines significantly improved the treatment of renal anemia in Japan. However, since 2008, many studies have assessed the treatment of renal anemia, and erythropoiesis-stimulating agents (ESAs) are now available. Therefore, the Executive Board of the JSDT decided that it was time to revise the guidelines to make them more appropriate to the situation of chronic kidney disease patients in Japan. This is the third edition of the guidelines for renal anemia published by the JSDT. The purpose is to improve the prognosis of chronic kidney disease patients, including after renal transplantation, through the treatment of renal anemia. The intended users of the guidelines are all healthcare professionals engaged in the treatment of chronic kidney disease. Regarding the treatment of adult dialysis and predialysis patients, statements and commentary are provided in the context of answers to clinical questions in Chapter 2 (Target Hb level and criteria for starting renal anemia treatment) and Chapter 4 (Evaluation of iron status and iron therapy). Furthermore, the essential information is provided alongside the critical issues in Chapter 1 (Diagnosis of renal anemia), Chapter 3 (Administration of ESAs—administration route and dose), Chapter 5 (ESA hyporesponsiveness), Chapter 6 (Side effects and concomitant symptoms of ESAs), and Chapter 7 (Red blood cell transfusion). In addition, the treatment of pediatric patients and post-renal transplant patients is discussed in Chapter 8 and Chapter 9, respectively.
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DOI：
10.1053/j.ajkd.2009.12.030
发表时间：
2010-04
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Babitt JL;Lin HY
通讯作者：
Lin HY
血液透析患者低剂量皮下注射促红细胞生成素的安全性和有效性。
DOI：
10.1681/asn.v82288
发表时间：
1997
期刊：
Journal of the American Society of Nephrology : JASN
影响因子：
--
作者：
Parker,KP;Mitch,WE;Stivelman,JC;Macon,EJ;Bailey,JL;Sands,JM
通讯作者：
Sands,JM
影响因子：
5.1
作者：
Mitsnefes, Mark M.;Kimball, Thomas R.;Daniels, Stephen R.
通讯作者：
Daniels, Stephen R.
CKD 中红细胞生成刺激剂的剂量和不良后果：荟萃回归分析。
DOI：
10.1053/j.ajkd.2012.07.014
发表时间：
2013-01
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Koulouridis I;Alfayez M;Trikalinos TA;Balk EM;Jaber BL
通讯作者：
Jaber BL
影响因子：
20.3
作者：
Ferrucci, Luigi;Semba, Richard D.;Longo, Dan L.
通讯作者：
Longo, Dan L.