Effects of Sex, Race, and Puberty on Cortical Bone and the Functional Muscle Bone Unit in Children, Adolescents, and Young Adults
Effects of Sex, Race, and Puberty on Cortical Bone and the Functional Muscle Bone Unit in Children, Adolescents, and Young Adults
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DOI：
10.1210/jc.2009-1913
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发表时间：
2010-04-01
影响因子：
5.8
通讯作者：
Zemel, Babette S.
中科院分区：
文献类型：
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作者：
Leonard, Mary B.;Elmi, Angelo;Zemel, Babette S.
背景：骨发育的性别和种族差异与生长、成熟和身体成分的差异有关。目的：本研究的目的是确定性别、种族和青春期对儿童和青少年皮质骨发育和肌肉-骨关系的独立影响。设计和参与者：我们对665名5-35岁的健康参与者(310名男性，306名黑人)进行了横断面研究。结果：胫骨外周CT测量皮质骨矿物质含量(BMC)和骨密度(BMD)，骨膜(Peri)和骨膜周长(Peri)，骨膜周长(ZP)和肌肉面积(ZP)。根据胫骨长度、年龄、种族、性别和Tanner分期调整回归模型。结果：黑人的所有皮质测量值均大于白人(均P
Context: Sex and race differences in bone development are associated with differences in growth, maturation, and body composition.Objective: The aim of the study was to determine the independent effects of sex, race, and puberty on cortical bone development and muscle-bone relations in children and young adults.Design and Participants: We conducted a cross-sectional study of 665 healthy participants (310 male, 306 black) ages 5-35 yr.Outcomes: Tibia peripheral quantitative computed tomography measures were made of cortical bone mineral content (BMC) and bone mineral density (BMD), periosteal (Peri) and endosteal circumferences, section modulus (Zp), and muscle area. Regression models were adjusted for tibia length, age, race, sex, and Tanner stage.Results: All cortical measures were greater in blacks than whites (all P