Histopathological findings in equine sinonasal disorders
Histopathological findings in equine sinonasal disorders
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DOI：
10.1111/j.2042-3306.1999.tb03820.x
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发表时间：
1999-07-01
影响因子：
2.2
通讯作者：
Dixon, PM
中科院分区：
文献类型：
--
作者：
Tremaine, WH;Clarke, CJ;Dixon, PM
从79例马鼻窦疾病转诊病例中收集的活检标本，其中包括27匹马患有原发性鼻窦炎，10匹马患有继发性牙窦炎，19匹马患有鼻窦囊肿，11匹马患有进行性筛窦血肿（PEH），4匹马患有假鼻孔表皮内含物囊肿，4匹马患有鼻窦息肉，3匹马患有鼻窦真菌病，并对2只对照动物进行了组织学检查，观察上皮类型和完整性、细胞炎症反应、纤维增生和潜在病原体的存在。慢性炎症变化，包括粘膜增厚，溃疡和显着的纤维组织增生，发现在窦粘膜与大多数鼻窦疾病，类似于人类慢性鼻窦炎。鼻窦炎粘膜上不常见细菌，但其病因学意义尚不清楚。在这些鼻窦炎病例中，存在明显不可逆的变化，包括纤维组织增生，这可能解释了他们对治疗的反应差或延迟，鼻窦囊肿与人类粘液囊肿在组织学上相似，进行性筛窦血肿显示了近期和较早的出血，鼻窦囊肿也是如此（偶尔一些慢性鼻窦炎切片），但鼻窦囊肿和PEH之间缺乏共同病因的支持。
Biopsies collected from 79 referred cases of equine sinonasal disease, including 27 horses with primary sinusitis, 10 with secondary dental sinusitis, 19 with sinus cysts, 11 with progressive ethmoid haematomata (PEH), 4 with false nostril epidermal inclusion cysts, 4 with sinonasal polyps, 3 with sinonasal mycosis and from 2 control animals were examined histologically, Observations were made on epithelial type and integrity, cellular inflammatory response, fibroplasia and presence of potential pathogens. Chronic inflammatory changes including mucosal thickening, ulceration and significant fibroplasia, were found in the sinus mucosa with most sinus disorders, similar to those found in human chronic sinusitis. Bacteria were variably present on sinusitis mucosae but their aetiological significance was unclear. The presence of apparently irreversible changes including fibroplasia in some of these sinusitis cases may explain their poor or delayed response to treatment, Sinus cysts had histological similarities to human mucocoeles, Progressive ethmoid haematomata showed recent and older haemorrhage, as did sinus cysts (and, occasionally some chronic sinusitis sections), but support for a common aetiology between sinus cysts and PEH was absent.