Discharge of inferior olive cells during reaching errors and perturbations
Discharge of inferior olive cells during reaching errors and perturbations
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DOI：
10.1016/j.brainres.2003.10.021
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发表时间：
2004-01-23
期刊：
影响因子：
2.9
通讯作者：
Gibson, AR
中科院分区：
文献类型：
--
作者：
Horn, KM;Pong, M;Gibson, AR
人们普遍认为，下橄榄（10）神经元信号的运动错误的发生。10将下降电机命令与有关运动的信息进行比较，并检测不匹配。据推测，这个错误信号被小脑用来改善运动性能。为了验证这一理论，我们训练猫根据提示伸出手、抓住并取回手柄。训练结束后，在选定的试验中将手柄移位，这样猫就能够到手柄，但却抓不到。55 10细胞与前肢感受野进行了测试与位移手柄条件。没有细胞在“预期”接触时或接近“预期”接触时发射，但当猫在试图抓取时撞击物体时，一些细胞发射。运动指令和预期结果之间的不匹配不足以激活10个神经元;必须进行适当的刺激。为了定义适当刺激的条件，在任务期间的不同时间刺激肢体。66个细胞（包括在移位手柄条件下测试的55个细胞）在安静站立时用机械刺激进行测试，98%的细胞对刺激有反应。一个较小的百分比（68%）发射时，刺激在达到任务，这些反应的概率与细分的橄榄以及任务的阶段。我们的结论是，这是不可能的，10放电提供有关运动或运动错误的信息。橄榄细胞对适当的体感刺激有可靠的反应，但对主动运动或运动错误没有反应。(C)2003 Elsevier B. V.保留所有权利。
It is widely believed that inferior olive (10) neurons signal the occurrence of movement errors. The 10 compares descending motor commands with information about movement and detects mismatches. Presumably, this error signal is used by the cerebellum to improve motor performance. To test this theory, we trained cats to reach out, grasp and retrieve a handle on cue. After training, the handle was displaced on selected trials so the cats would reach but miss the handle. Fifty-five 10 cells with receptive fields on the forelimb were tested with the displaced handle condition. No cell fired at or near the time of "expected" contact, but some cells fired when the cats struck objects while attempting to grasp. A mismatch between a motor command and expected result is not sufficient to activate 10 neurons; appropriate stimulation must occur. To define conditions for appropriate stimulation, the limb was stimulated at various times during the task. Sixty-six cells (including the 55 tested under the displaced handle condition) were tested with mechanical stimulation during quiet stance, and 98% responded to stimulation. A smaller percentage (68%) fired when stimulation was introduced during the reaching task, and the probability of these responses varied with the subdivision of the olive as well as the phase of the task. We conclude that it is unlikely that 10 discharge provides information about movement or movement error. Olivary cells respond reliably to appropriate somatosensory stimulation but not to active movement or movement error. (C) 2003 Elsevier B.V. All rights reserved.