Jaagsiekte sheep retrovirus is not detected in human lung adenocarcinomas expressing antigens related to the Gag polyprotein of betaretroviruses.
Jaagsiekte sheep retrovirus is not detected in human lung adenocarcinomas expressing antigens related to the Gag polyprotein of betaretroviruses.
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在表达与 β 逆转录病毒 Gag 多蛋白相关的抗原的人肺腺癌中未检测到 Jaagsiekte 绵羊逆转录病毒。
DOI：
10.1016/j.canlet.2007.08.006
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发表时间：
2007
期刊：
影响因子：
9.7
通讯作者：
Palmarini,Massimo
中科院分区：
文献类型：
--
作者：
DeLasHeras,Marcelo;Murcia,Pablo;Ortin,Aurora;Azua,Javier;Borderias,Luis;Alvarez,Ramiro;Jimenez-Mas,JoseAntonio;Marchetti,Antonio;Palmarini,Massimo
部分人肺腺癌 (hLAC) 表达与 Jaagsiekte 绵羊逆转录病毒 (JSRV) 主要衣壳蛋白 (CA) 相关的抗原，JSRV 是一种导致绵羊传染性肺癌的 Betaretrovirus。在这项研究中，我们研究了 JSRV 或相关的 β 逆转录病毒是否在 hLAC 中表达。获得的结果表明 JSRV 与人类肺腺癌无关。然而，一部分 hLAC 在免疫组织化学中与针对 JSRV Gag 不同结构域的特异性抗体发生阳性反应，表明真正的逆转录病毒抗原可以在这些肿瘤中表达。需要进一步的研究来确定在一些 hLAC 中检测到的抗原与 β 逆转录病毒 Gag 抗血清的交叉反应是否是由于人内源性逆转录病毒的表达，或更不可能是由于未表征的外源性逆转录病毒的表达。
A proportion of human lung adenocarcinomas (hLACs) express an antigen related to the major capsid protein (CA) of Jaagsiekte sheep retrovirus (JSRV), a Betaretrovirus that causes a transmissible lung cancer in sheep. In this study, we have investigated whether JSRV or related betaretroviruses are expressed in hLACs. Results obtained indicate that JSRV is not associated with human lung adenocarcinomas. However, a proportion of hLACs reacted positively in immunohistochemistry with antibodies specific towards different domains of the JSRV Gag suggesting that a bona fide retrovirus antigen could be expressed in these tumours. Further studies will be necessary to ascertain whether the detection of antigens cross-reacting with betaretrovirus Gag antisera in some hLACs is due to expression of a human endogenous retrovirus or, more unlikely, of an uncharacterized exogenous retrovirus.