FACTORS PROMOTING ACUTE AND CHRONIC DISEASES CAUSED BY YERSINIAE
FACTORS PROMOTING ACUTE AND CHRONIC DISEASES CAUSED BY YERSINIAE
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DOI：
10.1128/cmr.4.3.309-324.1991
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发表时间：
1991-07-01
影响因子：
36.8
通讯作者：
BRUBAKER, RR
中科院分区：
文献类型：
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作者：
BRUBAKER, RR
利用具有医学意义的耶尔森菌构建的实验体系，为急慢性疾病表达所需因子的比较研究提供了强有力的基础模型。该系统利用黑死病病原鼠疫耶尔森菌与肠致病性假结核耶尔森菌和小肠结肠炎耶尔森菌之间密切的遗传相似性。鼠疫杆菌具有三种质粒，其中一种为肠致病性物种所共有，可介导多种毒力因子，直接或间接促进巨噬细胞内的存活和免疫抑制。剩下的两个质粒是独特的，它们编码的功能通过增强细菌在组织中的传播和抵抗中性粒细胞和单核细胞的吞噬来促进急性疾病。这些特性在肠致病性耶尔森菌中被宿主细胞入侵和促进慢性疾病的粘附素所取代；后者在鼠疫杆菌中是隐性的。其他的区别还包括鼠疫杆菌的特定突变损失，这种损失导致在自然环境中适应性的丧失，加上通过跳蚤促进传播和感染的特性的增加。
The experimental system constructed with the medically significant yersiniae provides a powerful basic model for comparative study of factors required for expression of acute versus chronic disease. The system exploits the close genetic similarity between Yersinia pestis, the etiological agent of bubonic plague, and enteropathogenic Yersinia pseudotuberculosis and Yersinia enterocolitica. Y. pestis possesses three plasmids, of which one, shared by the enteropathogenic species, mediates a number of virulence factors that directly or indirectly promote survival within macrophages and immunosuppression. The two remaining plasmids are unique and encode functions that promote acute disease by enhancing bacterial dissemination in tissues and resistance to phagocytosis by neutrophils and monocytes. These properties are replaced in the enteropathogenic yersiniae by host cell invasins and an adhesin which promote chronic disease; the latter are cryptic in Y. pestis. Additional distinctions include specific mutational losses in Y. pestis which result in loss of fitness in natural environments plus gain of properties that facilitate transmission and infection via fleabite.