Tracheobronchial and alveolar dose of submicrometer particles for different population age groups in Italy
Tracheobronchial and alveolar dose of submicrometer particles for different population age groups in Italy
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DOI：
10.1016/j.atmosenv.2011.07.066
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发表时间：
2011-11-01
影响因子：
5
通讯作者：
Stabile, L.
中科院分区：
文献类型：
--
作者：
Buonanno, G.;Giovinco, G.;Stabile, L.
暴露于超细颗粒（直径小于100 nm）是流行病学和毒理学研究的重要课题。本研究使用的平均粒子数尺寸分布数据，从我们的测量调查中获得的主要微环境，以及从意大利人类活动模式调查获得的人的活动模式数据，估计气管支气管和肺泡剂量的亚微米颗粒物在意大利不同的人口年龄组。我们开发了一种基于蒙特卡罗方法的数值方法，以便从概率的角度估计最佳组合。根据专门建立的子程序分析了超过106个不同的病例，我们的结果表明，所有年龄组的每日肺泡颗粒数和表面积分别等于1.5 x 10（11）个颗粒和2.5 x 10（15）μ m（2），生活在北方或意大利南部的男性和女性略有不同。在气管支气管沉积方面，所有年龄组的每日颗粒数和表面积的相应值分别等于6.5 x 10（10）个颗粒和9.9 x 10（14）μ m（2）。总体而言，最大的贡献来自室内烹饪（女性），工作时间（男性）和交通（即交通衍生颗粒）（儿童）。(C)2011爱思唯尔有限公司版权所有。
Exposure to ultrafine particles (diameter less than 100 nm) is an important topic in epidemiological and toxicological studies. This study used the average particle number size distribution data obtained from our measurement survey in major microenvironments, together with the people activity pattern data obtained from the Italian Human Activity Pattern Survey to estimate the tracheobronchial and alveolar dose of submicrometer particles for different population age groups in Italy. We developed a numerical methodology based on Monte Carlo method, in order to estimate the best combination from a probabilistic point of view. More than 106 different cases were analyzed according to a purpose built sub-routine and our results showed that the daily alveolar particle number and surface area deposited for all of the age groups considered was equal to 1.5 x 10(11) particles and 2.5 x 10(15) mu m(2), respectively, varying slightly for males and females living in Northern or Southern Italy. In terms of tracheobronchial deposition, the corresponding values for daily particle number and surface area for all age groups was equal to 6.5 x 10(10) particles and 9.9 x 10(14) mu m(2), respectively. Overall, the highest contributions were found to come from indoor cooking (female), working time (male) and transportation (i.e. traffic derived particles) (children). (C) 2011 Elsevier Ltd. All rights reserved.