Obstacles to the development of a safe and effective attenuated pre-erythrocytic stage malaria vaccine
Obstacles to the development of a safe and effective attenuated pre-erythrocytic stage malaria vaccine
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DOI：
10.1016/j.micinf.2007.02.006
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发表时间：
2007-05-01
影响因子：
5.8
通讯作者：
Ballou, W. Ripley
中科院分区：
文献类型：
--
作者：
Ballou, W. Ripley
减毒红细胞前期疟疾疫苗保护人类免受孢子虫的攻击。目前的技术限制了其商业规模生产的可行性，并造成了传播媒介污染的重大风险。克服这些障碍将是非常具有挑战性的。相比之下，亚单位疫苗似乎相当可行，并显示出作为候选疟疾疫苗的巨大希望。(C) 2007 Elsevier Masson SAS。版权所有。
Attenuated pre-erythrocytic stage malaria vaccines protect humans from sporozoite challenge. Current technology limits the feasibility of their commercial scale production and poses a significant risk of contamination with transmissible agents. Overcoming these barriers will be very challenging. In contrast, subunit vaccines appear quite feasible and show great promise as candidate malaria vaccines. (C) 2007 Elsevier Masson SAS. All rights reserved.