Self-assembly of pH-responsive and fluorescent comb-like amphiphilic copolymers in aqueous media
Self-assembly of pH-responsive and fluorescent comb-like amphiphilic copolymers in aqueous media
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DOI：
10.1016/j.polymer.2010.05.032
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发表时间：
2010-07
期刊：
影响因子：
4.6
通讯作者：
Min Li;Guoliang Li;Zhiguo Zhang;Jun Li;K. Neoh;E. Kang
中科院分区：
文献类型：
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作者：
Min Li;Guoliang Li;Zhiguo Zhang;Jun Li;K. Neoh;E. Kang
"梳状"接枝共聚物，由聚（（N-乙烯基咔唑）-co-（4-乙烯基苄基氯））（P（NVK-co-VBC））共聚物主链和聚（2-二甲基氨基）乙基甲基丙烯酸酯）-co-（丙烯酸叔丁酯））来自原子转移自由基聚合（ATRP）的（P（DMAEMA-co-tBA））侧链，水解得到P（NVK-co-VBC）-comb-P（DMAEMA-co-AAc）的含丙烯酸（AAc）的"梳状"接枝共聚物。两亲性共聚物具有荧光疏水性P（NVK-co-VBC）主链和pH敏感性亲水性P（DMAEMA-co-AAc）侧链。由于亲水性侧链的酸碱相互作用，该共聚物可以在水介质中自组装成具有pH响应性的荧光和多壁中空囊泡。囊泡的尺寸和分层壁厚也取决于共聚物侧链的长度，而壁层的数量取决于囊泡在水性介质中的浓度。相比之下，具有类似结构的含N-异丙基丙烯酰胺（NIPAAm）的梳状两亲性共聚物（P（NVK-co-VBC）-comb-P（NIPAAm-co-DMAEMA）），尽管具有非相互作用的醇侧链，但在水性介质中仅自组装成温度和pH响应性单壳中空纳米颗粒。
“Comb-like” graft copolymers, consisting of a poly((N-vinylcarbazole)-co-(4-vinylbenzyl chloride)) (P(NVK-co-VBC)) copolymer backbone from free radical polymerization and poly(((2-dimethylamino)ethyl methacrylate)-co-(tert-butyl acrylate)) (P(DMAEMA-co-tBA)) side chains from atom transfer radical polymerization (ATRP), were hydrolyzed to produce the acrylic acid (AAc)-containing “comb-like” graft copolymers of P(NVK-co-VBC)-comb-P(DMAEMA-co-AAc). The amphiphilic copolymers possess a fluorescent hydrophobic P(NVK-co-VBC) backbone and pH-sensitive hydrophilic P(DMAEMA-co-AAc) side chains. Arising from acid–base interaction of the hydrophilic side chains, the copolymers can self-assemble into pH-responsive fluorescent and multi-walled hollow vesicles of well-defined morphology in aqueous media. The size and layered wall thickness of the vesicles are also dependent on the length of the copolymer side chains, while the number of wall layers is dependent on the concentration of the vesicles in the aqueous media. In comparison, a N-isopropylacrylamide (NIPAAm)-containing comb-like amphiphilic copolymer (P(NVK-co-VBC)-comb-P(NIPAAm-co-DMAEMA)) of similar structure, albeit with non-interacting hydropholic side chains, self-assembles only into temperature and pH-responsive single-shelled hollow nanoparticles in aqueous media.