IL‐18 and Antigen‐Specific CD4+ Regulatory T Cells in Peyer's Patches
IL‐18 and Antigen‐Specific CD4+ Regulatory T Cells in Peyer's Patches
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DOI：
10.1196/annals.1309.049
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发表时间：
2004-12
影响因子：
5.2
通讯作者：
N. Tsuji;B. Nowak
中科院分区：
文献类型：
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作者：
N. Tsuji;B. Nowak
翻译后摘要：一项使用基因缺陷小鼠的研究表明，IL-18是诱导抗原特异性调节性T细胞和口服耐受所必需的。还表明IL-18是免疫原性树突状细胞的功能性下调因子，有助于维持肠道免疫的稳态。
Abstract: A study using gene‐deficient mice revealed that IL‐18 is essential for inducing antigen‐specific regulatory T cells and oral tolerance. It is also suggested that IL‐18 is a functional downregulator for immunogenic dendritic cells, contributing to the maintenance of homeostasis for intestinal immunity.