Cellular immune response to infection with respiratory syncytial virus and influence of breast‐feeding on the response
Cellular immune response to infection with respiratory syncytial virus and influence of breast‐feeding on the response
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对呼吸道合胞病毒感染的细胞免疫反应以及母乳喂养对其反应的影响
DOI：
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发表时间：
1984
影响因子：
12.7
通讯作者：
T. Nakao
中科院分区：
文献类型：
--
作者：
K. Mito;Y. Chiba;K. Suga;T. Nakao
在78例因呼吸道合胞病毒（RSV）感染而患有各种疾病的婴儿中检查了体外病毒特异性淋巴细胞转化（LTF）活性。在73例下呼吸道疾病受试者中，通常在初始症状发作后一周内检测到显著的LTF活性，并在随后的上升中观察到每种临床形式的反应特征。因此，气管支气管炎受试者的平均活动逐渐增加，在发病后第四周检测到最大反应。在肺炎受试者中，在患病的第一周内反应相当低，然后在第二周观察到活动急剧增加。尽管毛细支气管炎患者在第一周前引起了类似水平的活性，但在随后的两周内，这种反应受到了显著抑制。第2周时，该组的反应性显著低于从肺炎（p <0.01）或气管支气管炎（p <0.05）患者中获得的相应标本，表明反应性与RSV诱导的细支气管炎的潜在机制密切相关。本研究进一步表明，RSV感染婴儿的母乳喂养可能会改变这些受试者的LTF活性水平。
Virus‐specific lymphocyte transformation (LTF) activity in vitro was examined in 78 infants with various forms of illness due to respiratory syncytial virus (RSV) infection. In 73 subjects with lower respiratory tract disease, significant LTF activity was often detected within one week after onset of initial symptoms, and responses characteristic for each clinical form were observed in the subsequent rise. Thus, mean activity in subjects with tracheobronchitis increased gradually, with the maximum response being detected at the fourth week after the onset of illness. In subjects with pneumonia the response was rather low during the first week of illness, and then a sharp increase of activity was observed at the second week. Although patients with bronchiolitis elicited similar levels of the activity until the first week, the response was significantly suppressed during the subsequent two weeks. The response at the second week in this group was significantly lower than those of corresponding specimens obtained from patients with pneumonia (p < 0.01) or tracheobronchitis (p < 0.05), suggesting a close association of the responsiveness with underlying mechanisms of bronchiolitis induced by RSV. The present study further indicated a possibility that breast‐feeding of RSV‐infected infants may alter levels of the LTF activity in these subjects.
对呼吸道合胞病毒感染的分泌抗体反应。
DOI：
10.1001/archpedi.1981.02130350017007
发表时间：
1981
期刊：
American journal of diseases of children (1960)
影响因子：
--
作者：
Kaul,TN;Welliver,RC;Wong,DT;Udwadia,RA;Riddlesberger,K;Ogra,PL
通讯作者：
Ogra,PL
支气管乳腺轴对呼吸道合胞病毒的免疫反应。
DOI：
10.1016/s0022-3476(81)80447-7
发表时间：
1981
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Fishaut,M;Murphy,D;Neifert,M;McIntosh,K;Ogra,PL
通讯作者：
Ogra,PL