Neuroimaging of mild behavioral impairment: A systematic review
Neuroimaging of mild behavioral impairment: A systematic review
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DOI：
10.1002/pcn5.81
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发表时间：
2023-02
期刊：
影响因子：
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通讯作者：
Teruyuki Matsuoka;Ayu Imai;J. Narumoto
中科院分区：
文献类型：
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作者：
Teruyuki Matsuoka;Ayu Imai;J. Narumoto
摘要目前对轻度行为障碍（MBI）的神经影像学研究很多，但结果不一致。此外，目前还不清楚MBI是否是痴呆症的危险因素或前驱症状。因此，进行了系统的回顾，总结MBI的神经影像学研究的结果，并考虑是否MBI是痴呆的前驱症状，其神经相关。使用PubMed、PsycINFO、CINAHL和Google Scholar于2022年11月1日确定的MBI神经影像学研究进行了一项由JSPS科学研究资助金（C）支持的系统性综述。入选标准为（i）神经影像学研究;（ii）人类受试者研究;（iii）英文论文;（iv）非病例研究、综述、书籍、评论或摘要。Joanna Briggs研究所的关键评价清单被用来评估所选研究的质量，23项结构和功能成像研究最终被纳入系统评价。结构研究表明MBI与海马、海马旁回、内嗅皮质和颞叶萎缩有关，而功能研究表明MBI涉及改变的默认模式网络、额顶控制网络和显着网络。许多研究中的一个局限性是使用了感兴趣区域分析。被检测为MBI的神经相关的脑区域被认为是在每种痴呆的早期阶段的改变。因此，MBI可能是在痴呆病理变化的背景下出现的。
Abstract There are many neuroimaging studies of mild behavioral impairment (MBI), but the results have been somewhat inconsistent. Moreover, it remains unclear whether MBI is a risk factor or prodromal symptom of dementia. Therefore, a systematic review was conducted to summarize the results of neuroimaging studies of MBI and consider whether MBI is a prodromal symptom of dementia in terms of its neural correlates. A systematic review supported by a JSPS Grant‐in‐Aid for Scientific Research (C) was conducted using MBI neuroimaging studies identified using PubMed, PsycINFO, CINAHL, and Google Scholar on November 1, 2022. The inclusion criteria were (i) neuroimaging study; (ii) research on human subjects; (iii) papers written in English; and (iv) not a case study, review, book, comments, or abstract only. Joanna Briggs Institute critical appraisal checklists were used to assess the quality of selected studies, and 23 structural and functional imaging studies were ultimately included in the systematic review. The structural studies suggested an association of MBI with atrophy in the hippocampus, parahippocampal gyrus, entorhinal cortex, and temporal lobe, whereas the functional studies indicated involvement of an altered default mode network, frontoparietal control network, and salience network in MBI. A limitation in many studies was the use of region‐of‐interest analysis. The brain areas detected as neural correlates of MBI are considered to be alterations in the early stage of each dementia. Therefore, MBI may emerge against a background of pathological changes in dementia.