Differential expression of the Drosophila mitofusin genes fuzzy onions (fzo) and dmfn
Differential expression of the Drosophila mitofusin genes fuzzy onions (fzo) and dmfn
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DOI：
10.1016/s0925-4773(02)00141-7
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发表时间：
2002-08-01
影响因子：
2.6
通讯作者：
Santel, A
中科院分区：
文献类型：
--
作者：
Hwa, JJ;Hiller, MA;Santel, A
Mitofusins comprise a family of evolutionarily conserved, nuclear encoded mitochondrial guanosine triphoshatases that control mitochondrial fusion and morphology. The fuzzy onions (fzo) and Drosophila mitofusin (dmfn) genes, which encode the only Mitofusin homologs in Drosophila are differentially expressed during development. Dmfn-mRNA was widely expressed during embryogenesis accumulating in the mesoderm and endoderm during gut development, during oogenesis with transcripts maternally deposited into the early embryo and in the male germ line, where dmfn-mRNA was expressed in spermatogonia, spermatocytes and early spermatids. In contrast, expression of the fzo was tightly restricted to the male germ line, with mRNA accumulation in spermatocytes and early spermatids. In addition, expression of dmfn and fzo in the same cell type, primary spermatocytes, was under control of different regulatory mechanisms. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
