ANALGESIA INDUCED BY NEONATAL CAPSAICIN TREATMENT IN RATS
ANALGESIA INDUCED BY NEONATAL CAPSAICIN TREATMENT IN RATS
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DOI：
10.1016/0091-3057(82)90155-1
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发表时间：
1982-01-01
影响因子：
3.6
通讯作者：
DUCLAUX, R
中科院分区：
文献类型：
--
作者：
SAUMET, JL;DUCLAUX, R
大鼠(27只)按475 mg·kg~(-1)皮下注射。辣椒素的寿命从2天到7天不等。经过治疗，只有11只老鼠存活了下来。治疗后50~170天测定皮肤热、压、刺痛和内脏高渗痛阈值。结果表明，对皮肤刺激和内脏刺激都有相当甚至全部的镇痛作用。结论是，相同的通路携带所有伤害性信息，而与伤害性刺激的性质或定位无关。
Rats (27) were treated by 475 mg kg-1 of s.c. capsaicin from 2 to 7 days of their life. After treatment, only 11 rats had survived. Their cutaneous heat, pressure, pricking and visceral hyperosmolarity nociceptive thresholds were measured 50-170 days after treatment. The results showed a considerable, or even total, analgesia to cutaneous as well as to visceral stimuli. The conclusion is that the same pathways carried all the nociceptive messages independently of nature or localization of noxious stimuli.