A Meta-Analysis of Tea Consumption and the Risk of Bladder Cancer
A Meta-Analysis of Tea Consumption and the Risk of Bladder Cancer
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DOI：
10.1159/000342804
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发表时间：
2013-01-01
影响因子：
1.6
通讯作者：
Xie, Li-Ping
中科院分区：
文献类型：
--
作者：
Wang, Xiao;Lin, Yi-Wei;Xie, Li-Ping
目的：以前关于喝茶与膀胱癌风险之间关系的研究只说明了相互矛盾的结果。茶在膀胱癌发生中的作用仍然存在争议。为了说明饮茶与膀胱癌之间的潜在关系，进行了病例对照和队列研究的荟萃分析。方法：通过计算机检索和参考文献综述检索符合条件的研究。对茶的类型、性别、研究设计、种族和吸烟状况进行了分层分析。使用固定或随机效应模型总结OR估计值和95% CI。结果：17项研究符合我们的分析。最高与最低茶叶摄入量比较，茶叶摄入量与膀胱癌风险之间无统计学意义（OR = 0.825，95%CI 0.652-1.043）。在绿色茶亚组中，我们观察到它对膀胱癌具有保护作用（OR = 0.814，95%CI 0.678-0.976）。结论：我们的分析表明，绿色茶可能对亚洲人的膀胱癌有保护作用。需要进行进一步的研究以更好地阐明生物学机制。版权所有（C）2012 S. Karger AG，巴塞尔
Objective: Previous studies on the association between tea consumption and bladder cancer risk have only illustrated contradictory results. The role of tea in bladder carcinogenesis still remains conflicting. In order to illustrate the potential relationship between tea consumption and bladder cancer, a meta-analysis of case-control and cohort studies was conducted. Methods: Eligible studies were retrieved via both computerized searches and review of references. Stratified analyses on types of tea, gender, study design, ethnicity and smoking status were performed. Fixed- or random-effect models were used to summarize the estimates of OR with 95% CIs. Results: Seventeen studies were eligible for our analysis. No statistical significance was detected between tea consumption and bladder cancer risk when comparing the highest with the lowest intake of tea (OR = 0.825, 95% CI 0.652-1.043). In the subgroup of green tea, we observed it illustrated a protective effect on bladder cancer (OR = 0.814, 95% CI 0.678-0.976). Conclusion: Our analysis indicated that green tea may have a protective effect on bladder cancer in Asian people. Further studies need to be conducted to better clarify the biological mechanisms. Copyright (C) 2012 S. Karger AG, Basel