Drosophila genetic variants that change cell size and rate of proliferation affect cell communication and hence patterning
Drosophila genetic variants that change cell size and rate of proliferation affect cell communication and hence patterning
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DOI：
10.1016/j.mod.2004.02.007
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发表时间：
2004-04-01
影响因子：
2.6
通讯作者：
García-Bellido, A
中科院分区：
文献类型：
--
作者：
Resino, J;García-Bellido, A
在这篇文章中，我们探讨了影响细胞大小和增殖的遗传变异在决定器官大小中的作用。我们在六个不同的基因座上使用功能丧失或功能获得的遗传马赛克，这促进了比正常细胞更小或更大的细胞，与比正常领土更小或更大的区域相关。这些变异对突变区域中的图案形成和生长具有自主影响。然而，突变区域的大小与细胞大小或增殖率之间没有相关性。此外，这些嵌合体对周围的野生型细胞表现出非自治的影响，总是包括非突变细胞数量的减少。在所有变异的条件下，翅膀的最终大小(和形状)都不同于正常。相同变异体的表型包括更高密度的小头毛节。这些自主和非自主的效应表明，机翼大小的控制是局部细胞交流的结果，定义了位置-价值景观中细胞之间的标准距离。(C)2004爱思唯尔爱尔兰有限公司。保留所有权利。
We explore in this paper the role of genetic variants that affect cell size and proliferation in the determination of organ size. We use genetic mosaics of loss or gain of function in six different loci, which promotes smaller or larger than normal cells, associated to either smaller or larger than normal territories. These variants have autonomous effects on patterning and growth in mutant territories. However, there is no correlation between cell size or rate of proliferation on the size of the mutant territory. In addition, these mosaics show non-autonomous effects on surrounding wildtype cells, consisting always in a reduction in number of non-mutant cells. In all mutant conditions the final size (and shape) of the wing is different than normal. The phenotypes of the same variants include higher density of chaetae in the notum. These autonomous and non-autonomous effects suggest that the control of size in the wing is the result of local cell communication defining canonic distances between cells in a positional-values landscape. (C) 2004 Elsevier Ireland Ltd. All rights reserved.