Nuclear receptor estradiol complex: a requirement for uterotrophic responses.
Nuclear receptor estradiol complex: a requirement for uterotrophic responses.
复制标题
核受体雌二醇复合物：子宫营养反应的必要条件。
作者：
J. Anderson;E. Peck;J. H. Clark
对受体雌激素复合物的形成是诱导子宫增重反应的必要条件这一假设进行了检验。未成熟大鼠单次注射2.5 μg雌二醇，可使受体雌激素复合物迅速积聚于大鼠子宫核部分。然而，当细胞质受体的量非常低时，在初始注射后3小时的第二次注射不会提高核受体含量。如果雌激素受体与子宫对雌二醇的敏感性有因果关系，则可以预期在雌二醇治疗后3小时子宫反应也对雌激素不敏感。为了检查这种可能性，用雌二醇预处理3小时的大鼠接受额外的雌二醇注射，并测定短期（湿重和葡萄糖氧化）和长期（湿重和干重）反应的程度。第二次注射未能增加短期或长期子宫反应的幅度。H...
The hypothesis that the formation of the receptor estrogen complex is a requirement for the induction of uterotrophic responses was tested. A single injection of 2.5 μg of estradiol given to immature rats results in the rapid accumulation of the receptor estrogen complex by the nuclear fraction of rat uteri. However, a second injection at 3 hr following the initial injection, when the amount of cytoplasmic receptor is very low, does not elevate nuclear receptor content. If the estrogen receptor is causally related to uterine sensitivity to estradiol one would expect that uterine responses would also be insensitive to estrogen at 3 hr after estradiol treatment. To examine this possibility, rats which were pretreated with estradiol for 3 hr received an additional estradiol injection and the extent of short (wet weight and glucose oxidation) and long term (wet and dry weight) responses was determined. The second injection failed to increase the magnitude of either short term or long term uterine responses. H...