Primers on Molecular Pathways - The NFAT Transcription Pathway in Pancreatic Cancer
Primers on Molecular Pathways - The NFAT Transcription Pathway in Pancreatic Cancer
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DOI：
10.1159/000315035
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发表时间：
2010-01-01
期刊：
影响因子：
3.6
通讯作者：
Ellenrieder, Volker
中科院分区：
文献类型：
--
作者：
Koenig, Alexander;Fernandez-Zapico, Martin E.;Ellenrieder, Volker
激活 T 细胞钙调神经磷酸酶反应性核因子 (NFAT) 转录因子家族最初被确定为一组诱导型核蛋白，在 T 淋巴细胞激活过程中调节转录。然而，在最初发现之后，大量研究很快证实 NFAT 蛋白也在免疫系统外的细胞中表达，它们参与调节影响细胞生长和分化的基因表达。现在，个体 NFAT 成员的异位激活被认为是多种人类恶性肿瘤（尤其是胰腺癌）致癌转化的一个重要方面。 Ca2+/钙调神经磷酸酶/NFAT 信号通路的持续激活已成为控制胰腺癌细胞生长的强大调节原理。激活的 NFAT 蛋白与关键致癌蛋白形成复合物，调节主细胞周期调节因子和具有细胞存活、迁移和血管生成功能的蛋白的转录。这篇综述特别关注我们对 NFAT 转录途径如何在胰腺癌的发生和进展过程中控制基因表达的理解的最新进展。版权所有 (C) 2010 S. Karger AG，巴塞尔和 IAP
The calcineurin-responsive nuclear factor of activated T cells (NFAT) family of transcription factors was originally identified as a group of inducible nuclear proteins, which regulate transcription during T lymphocyte activation. However, following their initial discovery, a multitude of studies quickly established that NFAT proteins are also expressed in cells outside the immune system, where they participate in the regulation of the expression of genes influencing cell growth and differentiation. Ectopic activation of individual NFAT members is now recognized as an important aspect for oncogenic transformation in several human malignancies, most notably in pancreatic cancer. Sustained activation of the Ca2+/calcineurin/NFAT signaling pathway has emerged as a powerful regulatory principle governing pancreatic cancer cell growth. Activated NFAT proteins form complexes with key oncogenic proteins to regulate the transcription of master cell cycle regulators and proteins with functions in cell survival, migration and angiogenesis. This review pays particular attention to recent advances in our understanding of how the NFAT transcription pathway controls gene expression during development and progression of pancreatic cancer. Copyright (C) 2010 S. Karger AG, Basel and IAP