Implantable and self-powered blood pressure monitoring based on a piezoelectric thinfilm: Simulated, in vitro and in vivo studies
Implantable and self-powered blood pressure monitoring based on a piezoelectric thinfilm: Simulated, in vitro and in vivo studies
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基于压电薄膜的植入式自供电血压监测：模拟、体外和体内研究
DOI：
10.1016/j.nanoen.2016.02.037
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发表时间：
2016-04-01
期刊：
影响因子：
17.6
通讯作者：
Zhang, Haixia
中科院分区：
文献类型：
--
作者：
Cheng, Xiaoliang;Xue, Xiang;Zhang, Haixia
本研究旨在通过理论、体外和体内研究，评估基于压电薄膜（PETF）的植入式自供电血压（BP）监测器的可行性和有效性。三维仿真模型显示，主动脉壁的应力和装置产生的电势均与收缩压成正比。在体外测试系统中，器件的峰值输出电压与流压之间具有良好的线性关系（R-2 > 0.99），灵敏度高达173 mV/mmHg，明显高于文献报道的结果。在体外达到2.3 μ W的最大瞬时功率，表明具有强大的自供电能力。该器件在超过50，000次操作循环中也实现了出色的稳定性。在成年约克郡猪中进行了体内试验。该器件具有良好的线性（R-2=0.971），灵敏度为1432 mV/mmHg，在体输出最大瞬时功率为40 nW。基于该装置的这些特点，我们建立了一个植入式，自供电和可视化的血压监测系统，在体外和体内演示。高血压状态可以使用该系统实时视觉报警，而无需内置电池。这种新技术结合了能量采集和生物医学传感的耦合功能，在植入式医疗监护领域显示出了很好的前景。(C)2016爱思唯尔有限公司版权所有
This research is aimed to evaluate the feasibility and efficacy of a piezoelectric thinfilm (PETF) based, implantable and self-powered monitor for blood pressure (BP) through theoretical, in vitro and in vivo studies. A 3-dimensional simulation model revealed that both the stresses of aorta wall and the generated electric potential by device were proportional to systolic BP. With an in vitro testing system, an excellent linearity (R-2 > 0.99) was achieved between the peak output voltage of device and flow pressure, with a high-sensitivity of 173 mV/mmHg which is significantly higher than reported results. A maximum instantaneous power of 2.3 mu W was reached in vitro, indicating a robust self-powered capability. Excellent stability of the device was also achieved for more than 50,000 operating cycles. In vivo experiment was carried out in adult Yorkshire porcine. A favorable linearity (R-2=0.971) with a sensitivity of 1432 mV/mmHg was obtained, and the device output a maximal instantaneous power of 40 nW in vivo. Based on these characteristics of the device, we established an implantable, self-powered and visualized blood pressure monitoring system for in vitro and in vivo demonstration. A hypertension status could be alarmed visually in real-time using this system, without a built-in battery. Integrated with a coupling function of energy harvesting and biomedical sensing, this new technique shows a promising perspective in the field of the implantable healthcare monitoring. (C) 2016 Elsevier Ltd. All rights reserved.