The likelihood of persistent arthritis increases with the level of anti-citrullinated peptide antibody and immunoglobulin M rheumatoid factor: a longitudinal study of 376 patients with very early undifferentiated arthritis.
The likelihood of persistent arthritis increases with the level of anti-citrullinated peptide antibody and immunoglobulin M rheumatoid factor: a longitudinal study of 376 patients with very early undifferentiated arthritis.
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DOI：
10.1186/ar2995
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发表时间：
2010
影响因子：
4.9
通讯作者：
Kvien TK
中科院分区：
文献类型：
--
作者：
Mjaavatten MD;van der Heijde D;Uhlig T;Haugen AJ;Nygaard H;Sidenvall G;Helgetveit K;Kvien TK
我们想评估抗瓜氨酸肽抗体（抗CCP）和免疫球蛋白M（IgM）类风湿因子（RF）水平在预测未分化关节炎（UA）发展为持续性关节炎中的重要性，并研究抗CCP和IgM RF检测是否对持续性关节炎有额外的预测价值。对纳入挪威极早期关节炎诊所的UA患者（排除明确的非类风湿性关节炎（RA）诊断）进行持续性关节炎疾病发展评估。研究了抗体水平对持续性关节炎可能性的影响，并确定了抗CCP和IgM RF单独和组合对持续性关节炎的敏感性和特异性。共纳入376例UA患者（中位关节炎持续时间为32天）。IgM RF阳性59例（15.7%），抗CCP阳性62例（16.5%）。174例（46.3%）在一年后仍有疾病。抗CCP抗体与IgM RF重叠阳性率为58%。持续性关节炎的敏感性/特异性为28/95%单独IgM RF，30/95%单独抗CCP，37/92%抗CCP和IgM RF阳性。持续性疾病的可能性随着抗CCP和IgM RF水平的增加而增加。UA患者发生持续性关节炎的可能性随着抗CCP和IgM RF水平的升高而增加。抗CCP和IgM RF检测增加了UA患者的预测价值。这项研究表明，在UA患者中进行风险评估时，应考虑抗体水平。
We wanted to assess the importance of the levels of anti-citrullinated peptide antibody (anti-CCP) and immunoglobulin M (IgM) rheumatoid factor (RF) in predicting development of persistent arthritis from undifferentiated arthritis (UA), and to investigate whether there is an added predictive value for persistent arthritis in testing for both anti-CCP and IgM RF. Patients with UA (exclusion of definite non-rheumatoid arthritis (RA) diagnoses) included in the Norwegian very early arthritis clinic were assessed for development of persistent arthritic disease. The effect of antibody level on the likelihood of persistent arthritis was investigated, and the sensitivity and specificity for persistent arthritis for anti-CCP and IgM RF, separately and combined, was determined. A total of 376 UA patients were included (median arthritis duration 32 days). 59 (15.7%) patients were IgM RF positive, and 62 (16.5%) anti-CCP positive. One hundred, seventy-four (46.3%) had persistent disease after one year. Overlap of anti-CCP and IgM RF positivity was 58%. Sensitivity/specificity for persistent arthritis was 28/95% for IgM RF alone, 30/95% for anti-CCP alone, and 37/92% for positivity of both anti-CCP and IgM RF. The likelihood for persistent disease increased with increasing levels of both anti-CCP and IgM RF. The likelihood of developing persistent arthritis in UA patients increases with the level of anti-CCP and IgM RF. Testing both anti-CCP and IgM RF has added predictive value in UA patients. This study suggests that antibody level should be taken into account when making risk assessments in patients with UA.
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影响因子：
5.5
作者：
Scott, DL
通讯作者：
Scott, DL
DOI：
10.3899/jrheum.080895
发表时间：
2009-04
期刊：
The Journal of rheumatology
影响因子：
--
作者：
Chibnik LB;Mandl LA;Costenbader KH;Schur PH;Karlson EW
通讯作者：
Karlson EW
影响因子：
27.4
作者：
Bos, W. H.;Wolbink, G. J.;van Schaardenburg, D.
通讯作者：
van Schaardenburg, D.
影响因子：
3.4
作者：
Kudo-Tanaka, Eriko;Ohshima, Shiro;Saeki, Yukihiko
通讯作者：
Saeki, Yukihiko
影响因子：
2.1
作者：
KAARELA, K;KAUPPI, MJ;LEHTINEN, KES
通讯作者：
LEHTINEN, KES