DNA-based catalytic enantioselective intermolecular oxa-Michael addition reactions
DNA-based catalytic enantioselective intermolecular oxa-Michael addition reactions
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DOI：
10.1039/c2cc31854g
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发表时间：
2012-01-01
影响因子：
4.9
通讯作者：
Roelfes, Gerard
中科院分区：
文献类型：
--
作者：
Megens, Rik P.;Roelfes, Gerard
利用基于DNA的催化概念，报道了一种新型的铜(II)催化醇与烯酮的不对称氧迈克尔加成反应。对映体选择性高达86%。水的存在对反应活性很重要，可能是通过逆转不想要的副反应，如1，2-加成。
Using the DNA-based catalysis concept, a novel Cu(II) catalyzed enantioselective oxa-Michael addition of alcohols to enones is reported. Enantioselectivities of up to 86% were obtained. The presence of water is important for the reactivity, possibly by reverting unwanted side reactions such as 1,2-additions.