Smoking status and its relationship to demographic and clinical characteristics in first episode psychosis
Smoking status and its relationship to demographic and clinical characteristics in first episode psychosis
复制标题
DOI：
10.1016/j.jpsychires.2016.10.022
复制
发表时间：
2017-02-01
影响因子：
4.8
通讯作者：
Iyer, Srividya N.
中科院分区：
文献类型：
--
作者：
Grossman, Michael;Bowie, Christopher R.;Iyer, Srividya N.
在精神病发作之前就观察到吸烟率升高，并在疾病早期保持稳定。大麻的使用经常与吸烟同时发生，并且与不同的临床结果独立相关。然而，过去的研究并未控制患有首发精神病（FEP）的吸烟者使用大麻的情况，限制了关于吸烟与这些患者的人口统计和临床特征的独特关系的结论。因此，本研究的目的是：（1）确定 FEP 中吸烟及其与大麻共同使用的流行率和模式，以及（2）在调整大麻使用频率后，检查与吸烟状况相关的人口、临床、认知和功能特征。接受 FEP 专门治疗的患者 (N = 140) 根据其当前吸烟状况分为几组：66 名非吸烟者（0 支/天）、47 名轻度/中度吸烟者（1-19 支/天；M = 9.81，SD = 3.93）和 27 名重度吸烟者（>= 20 支/天；M = 26.39，SD = 3.93）。 6.31）。吸烟率为 53%，吸烟状况与大麻使用频率高度相关。在调整大麻使用后，出现了显着的组间差异。与轻度/中度吸烟者和不吸烟者相比，重度吸烟者在进入项目时年龄较大，并且精神病发病年龄较晚。与轻度/中度和重度吸烟者相比，非吸烟者受教育程度更高，神经认知表现更好，功能水平更高。需要进行前瞻性纵向研究，以更好地了解烟草使用的临床意义以及导致 FEP 中吸烟行为开始和持续的因素。 (C) 2016 Elsevier Ltd. 保留所有权利。
Elevated rates of cigarette smoking are observed prior to the onset of psychosis and remain stable early in the illness. Cannabis use frequently co-occurs with cigarette smoking and is independently associated with distinct clinical outcomes. However, past research has not controlled for cannabis use in cigarette smokers with first episode psychosis (FEP), limiting conclusions on the unique relationship of cigarette smoking to the demographic and clinical profiles of these patients. The present study therefore aimed to: (1) Determine the prevalence and patterns of cigarette smoking and its co-use with cannabis in FEP, and (2) Examine the demographic, clinical, cognitive, and functional characteristics associated with cigarette smoking status, after adjusting for frequency of cannabis use. Patients entering specialized treatment for FEP (N = 140) were divided into groups according to their current smoking status: 66 non-smokers (0 cigarettes/day), 47 light/moderate smokers (1-19 cigarettes/day; M = 9.81, SD = 3.93), and 27 heavy smokers (>= 20 cigarettes/day; M = 26.39, SD = 6.31). The prevalence of cigarette smoking was 53% and smoking status was highly associated with frequency of cannabis use. After adjusting for cannabis use, significant between-group differences emerged. Heavy smokers were older at program entry and had a later age of onset of psychosis than light/moderate and non-smokers. Non-smokers had more education, better neurocognitive performance, and higher levels of functioning than light/moderate and heavy smokers. Prospective, longitudinal studies are needed to better understand the clinical significance of tobacco use and factors that contribute to the initiation and continuation of smoking behaviours in FEP. (C) 2016 Elsevier Ltd. All rights reserved.