Critical Role for TSLC1 Expression in the Growth and Organ Infiltration of Adult T-Cell Leukemia Cells In Vivo
Critical Role for TSLC1 Expression in the Growth and Organ Infiltration of Adult T-Cell Leukemia Cells In Vivo
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DOI：
10.1128/jvi.01149-08
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发表时间：
2008-12-01
影响因子：
5.4
通讯作者：
Morishita, Kazuhiro
中科院分区：
文献类型：
--
作者：
Dewan, M. Zahidunnabi;Takamatsu, Naofumi;Morishita, Kazuhiro
成人T细胞白血病（ATL）与人类T细胞白血病病毒1型感染有关。肿瘤抑制性肺癌1（TSLC 1）基因先前被确定为ATL的一种新的细胞表面标记物，本研究证明了TSLC 1表达参与ATL细胞的肿瘤生长和器官浸润。在使用NOD/SCID/γ c（null）小鼠的实验中，具有高TSLC 1表达的白血病细胞系和原代ATL细胞均引起更多的肿瘤形成和小鼠各种器官的侵袭性浸润。我们的研究结果表明，ATL细胞中TSLC 1的表达在ATL细胞的生长和器官浸润中起着重要作用。
Adult T-cell leukemia (ATL) is associated with human T-cell leukemia virus type 1 infection. The tumor suppressor lung cancer 1 (TSLC1) gene was previously identified as a novel cell surface marker for ATL, and this study demonstrated the involvement of TSLC1 expression in tumor growth and organ infiltration of ATL cells. In experiments using NOD/SCID/gamma c(null) mice, both leukemia cell lines and primary ATL cells with high TSLC1 expression caused more tumor formation and aggressive infiltration of various organs of mice. Our results suggest that TSLC1 expression in ATL cells plays an important role in the growth and organ infiltration of ATL cells.